Technology Process of 3-fluoro-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-(phenylsulfonyl)-1H-indazol-4-amine
There total 8 articles about 3-fluoro-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-(phenylsulfonyl)-1H-indazol-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
at 120 ℃;
microwave vial;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Inert atmosphere
1.2: 0.5 h / Inert atmosphere; Cooling with ice
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -50 °C
2.2: 1.33 h / -50 - -30 °C
2.3: -30 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 120 °C / microwave vial
With
sodium hydride; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Inert atmosphere
1.2: 0.5 h / Inert atmosphere; Cooling with ice
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -50 °C
2.2: 1.33 h / -50 - -30 °C
2.3: -30 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 120 °C / microwave vial
With
sodium hydride; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;