H-D-PHE-PRO-OH TRIFLUOROACETATE SALT

Base Information

• Chemical Name: H-D-PHE-PRO-OH TRIFLUOROACETATE SALT
• CAS No.: 51926-52-4
• Molecular Formula: C14H18 N2 O3
• Molecular Weight: 262.309
• Hs Code.: 2933990090
• Mol file: 51926-52-4.mol

Synonyms:L-Proline,1-D-phenylalanyl-; 147: PN: WO2005000193 SEQID: 147 claimed sequence; 32: PN:EP2085120 SEQID: 32 claimed sequence; 32: PN: WO2009095265 SEQID: 32 claimedsequence; D-Phenylalanyl-L-proline

Chemical Property of H-D-PHE-PRO-OH TRIFLUOROACETATE SALT

Chemical Property:

• Vapor Pressure: 3.25E-11mmHg at 25°C
• Boiling Point: 509.7°Cat760mmHg
• Flash Point: 262.1°C
• PSA: 83.63000
• Density: 1.282g/cm³
• LogP: 1.27020
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-D-PHE-PRO-OH TRIFLUOROACETATE SALT

There total 1 articles about H-D-PHE-PRO-OH TRIFLUOROACETATE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-D-Phe (2448-45-5) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → D-Phe-L-Pro (51926-52-4,28819-11-6)

Guidance literature:

With sodium hydroxide; diethyl ether; phosphorus pentachloride; Hydrieren des Reaktionsprodukts an Palladium in wss. Essigsaeure enthaltendem Methanol;

Reference yield:

D-Phe-L-Pro (51926-52-4,28819-11-6) → Gramicidin S (113-73-5)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/ja9705755

Reference yield:

D-Phe-L-Pro (51926-52-4,28819-11-6) → C30H34N6O8S2 (276245-69-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetone / 4 h / 4 °C

2: EDCI*HCl; Et₃N / acetonitrile / 16 h / 4 °C

3: HCl(g) / dioxane / 96 h / 4 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; acetone; acetonitrile; 1: Condensation / 2: Condensation / 3: Addition;

DOI:10.1021/jm9903693

upstream raw materials:

Cbz-D-Phe

L-proline

Downstream raw materials:

Gramicidin S

cyclo[-D-Phe-Pro-Val-Lys-Leu]2

C₂₉H₃₀N₆O₇S₂

C₃₀H₃₄N₆O₈S₂