Technology Process of (2S,3R,4R,5S,6R)-2-[3-((5-(4-fluorophenyl)thienyl)-2-methylene)-4-chloro-phenyl]-6-methylsulfonyltetrahydropyran-3,4,5-triol
There total 13 articles about (2S,3R,4R,5S,6R)-2-[3-((5-(4-fluorophenyl)thienyl)-2-methylene)-4-chloro-phenyl]-6-methylsulfonyltetrahydropyran-3,4,5-triol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; sodium methylate;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium chloride; isopropylmagnesium chloride / tetrahydrofuran / 1 h / Cooling with ice
1.2: 1 h
2.1: cerium(III) chloride heptahydrate / methanol / 0.33 h / 20 °C
2.2: 1 h / -78 °C
3.1: acetic acid / water / 15 h / 100 °C
3.2: 2 h / 20 °C / Cooling with ice
4.1: hydrogen bromide; acetic acid / 1 h / 20 °C / Cooling with ice
5.1: thiourea / acetonitrile / 1 h / Reflux
6.1: triethylamine / 1 h / 20 °C
7.1: urea hydrogen peroxide adduct / acetonitrile; methanol / 20 °C
8.1: methanol; sodium methylate / 20 °C
With
methanol; cerium(III) chloride heptahydrate; hydrogen bromide; isopropylmagnesium chloride; sodium methylate; urea hydrogen peroxide adduct; acetic acid; triethylamine; thiourea; lithium chloride;
In
tetrahydrofuran; methanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: urea hydrogen peroxide adduct / acetonitrile; methanol / 20 °C
2: methanol; sodium methylate / 20 °C
With
methanol; sodium methylate; urea hydrogen peroxide adduct;
In
methanol; acetonitrile;