etoposide

Base Information

• Chemical Name: etoposide
• CAS No.: 163959-36-2
• Molecular Formula: C₂₉H₃₂O₁₃
• Molecular Weight: 588.565
• Mol file: 163959-36-2.mol

Synonyms:etoposide

Chemical Property of etoposide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of etoposide

There total 1 articles about etoposide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4′-demethylpodophyllotoxin-4-O-β-D-glucopyranoside (40505-30-4) + diethyl acetal (105-57-7,30846-29-8) → etoposide (163959-36-2)

Guidance literature:

With toluene-4-sulfonic acid; In nitromethane; for 6h;

Reference yield:

etoposide (163959-36-2) → picroetoposide (33419-42-0,89301-95-1,96554-38-0,96554-41-5,100007-53-2,100007-56-5,112246-48-7,112246-49-8,112246-50-1,132880-83-2,134623-79-3,136232-35-4,136232-37-6,136232-38-7,140223-11-6)

Guidance literature:

With water; at 37 ℃; phosphate buffer (pH: 7.4); or with human serum albumin;

DOI:10.1248/cpb.38.180

Reference yield:

etoposide (163959-36-2) → (5R,6S,7R,8R)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: water / 37 °C / phosphate buffer (pH: 7.4); or with human serum albumin

2: water / 37 °C / phosphate buffer (pH: 7.4); human serum albumin

With water;

DOI:10.1248/cpb.38.180

upstream raw materials:

4′-demethylpodophyllotoxin-4-O-β-D-glucopyranoside

diethyl acetal

Downstream raw materials:

picroetoposide

Refernces