3-Cloro-1-phenylpropyl butanoate

Base Information

• Chemical Name: 3-Cloro-1-phenylpropyl butanoate
• CAS No.: 293322-40-4
• Molecular Formula: C₁₃H₁₇ClO₂
• Molecular Weight: 240.73
• Mol file: 293322-40-4.mol

Synonyms:3-Cloro-1-phenylpropyl butanoate

Chemical Property of 3-Cloro-1-phenylpropyl butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Cloro-1-phenylpropyl butanoate

There total 2 articles about 3-Cloro-1-phenylpropyl butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

butanoic acid anhydride (106-31-0) + 3-chloro-1-phenyl-propan-1-ol (18776-12-0,125712-82-5) → 3-Cloro-1-phenylpropyl butanoate (293322-40-4)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/b000846j

Reference yield:

3-chloropropiophenone (936-59-4) → 3-Cloro-1-phenylpropyl butanoate (293322-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaBH₄ / ethanol / 2 h / 20 °C

2: 93 percent / pyridine; DMAP / CH₂Cl₂ / 0 - 20 °C

With pyridine; dmap; sodium tetrahydroborate; In ethanol; dichloromethane; 1: Reduction / 2: Esterification;

DOI:10.1039/b000846j

Reference yield:

3-Cloro-1-phenylpropyl butanoate (293322-40-4) → 3-chloro-1-phenylpropanol (100306-34-1,125712-82-5) + (1R)-3-chloro-1-phenylpropanol (100306-33-0,125712-82-5)

Guidance literature:

With phosphate buffer; novozyme 435; at 30 ℃; for 288h; pH=7; Title compound not separated from byproducts;

DOI:10.1039/b000846j

upstream raw materials:

butanoic acid anhydride

3-chloro-1-phenyl-propan-1-ol

3-chloropropiophenone

Downstream raw materials:

3-chloro-1-phenylpropanol

(1R)-3-chloro-1-phenylpropanol

(R)-tomoxetine

(R)-fluoxetine

Refernces