9-ETHYLGUANINE

Base Information

• Chemical Name: 9-ETHYLGUANINE
• CAS No.: 879-08-3
• Molecular Formula: C7H9 N5 O
• Molecular Weight: 179.181
• Hs Code.: 29335990
• Mol file: 879-08-3.mol

Synonyms:Guanine,9-ethyl- (6CI,7CI,8CI); 9-Ethylguanine; NSC 22755

Chemical Property of 9-ETHYLGUANINE

Chemical Property:

• Vapor Pressure: 1.33E-09mmHg at 25°C
• Melting Point: >300 °C
• Boiling Point: 486.1ºC at 760 mmHg
• PKA: 9.65±0.20(Predicted)
• Flash Point: 247.8ºC
• PSA: 89.59000
• Density: 1.68g/cm3
• LogP: 0.30290
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

9-Ethylguanine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 9-Ethylguanine is a DNA model base used to study DNA interactions with organometallic complexes, especially those designed to target tumors.

Technology Process of 9-ETHYLGUANINE

There total 19 articles about 9-ETHYLGUANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-ethyl-5-<(thiocarbamoyl)amino>-1H-imidazole-4-carboxamide (131490-68-1) → 9-Ethylguanine (879-08-3)

Guidance literature:

With sodium hydroxide; copper diacetate; for 1h; Heating;

DOI:10.1021/jo00006a033

Reference yield: 70.0%

C14H15N5O → 9-Ethylguanine (879-08-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; at 25 ℃;

DOI:10.1007/BF02290890

Reference yield: 53.0%

2-amino-7-benzyl-9-ethyl-6-oxo-6,7-dihydro-1H-purin-9-ium; benzenesulfonate → 9-Ethylguanine (879-08-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 75 - 80 ℃;

DOI:10.1007/BF02290890

upstream raw materials:

2,5-diamino-1H-pyrimidine-4,6-dione

Ethyl isothiocyanate

2-amino-6-chloro-9-ethyl-9H-purine

1-ethyl-5-<(thiocarbamoyl)amino>-1H-imidazole-4-carboxamide

Downstream raw materials:

[(η6:η1-2-phenethylamine)Ru(9-ethylguanine)Cl]Cl

(η6-biphenyl)(6-methylpicolinato)(9-ethylguanine-N1)osmium(II)(1+)

(η6-biphenyl)(2,4-pyridinedicarboxylato)(9-ethylguanine-N1)osmium(II)(1+)

(η6-biphenyl)(4-methylpicolinato)(9-ethylguanine-N1)osmium(II)(1+)

Refernces

• 1、 Fosu-Mensah, Nelly A.,Jiang, Wen,Brancale, Andrea,Cai, Jun,Westwell, Andrew D.. "The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein–protein interaction". . p. 182 - 202. Retrieved 2019/01/04.
• 2、 Michael,Cottam,Smee,Robins,Kini. "Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines.". . p. 3431 - 3436. Retrieved 2007/10/02.