(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt

Base Information

• Chemical Name: (2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt
• CAS No.: 848469-32-9
• Molecular Formula: C₁₀H₁₆O₄S*C₁₆H₁₄F₃N₅O
• Molecular Weight: 581.616
• Mol file: 848469-32-9.mol

Synonyms:(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt

Chemical Property of (2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt

There total 2 articles about (2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) + voriconazole (137234-62-9,137234-63-0,173967-54-9,188416-29-7) → (2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt (848469-32-9)

Guidance literature:

In methanol; acetone; at 30 - 50 ℃; for 1.33333h; Heating / reflux;

Reference yield:

(1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) + 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol (137234-63-0,173967-54-9,188416-29-7) → (2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt (848469-32-9) + (2S,3R)-voriconazole (1S)-(+)-10-camphorsulfonate (137234-72-1)

Guidance literature:

In methanol; ethyl acetate; Reflux; Resolution of racemate;

Reference yield: 76.0%

(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt (848469-32-9) → voriconazole (137234-62-9,137234-63-0,173967-54-9,188416-29-7)

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 20 ℃; for 0.333333h; pH=~ 10; Product distribution / selectivity;

upstream raw materials:

(1S)-10-camphorsulfonic acid

voriconazole

2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol

Downstream raw materials:

voriconazole

Refernces

• 1、 -. "PROCESS FOR PREPARING VORICONAZOLE". Page/Page column 19. . Retrieved 2010/11/08.