32-Ethyl-14,16,18,20,22,24,26,28-octahydroxy-15,31-dimethyl-1-oxacyclodotriaconta-3,5,7,9,11,29-hexaen-2-one

Base Information

• Chemical Name: 32-Ethyl-14,16,18,20,22,24,26,28-octahydroxy-15,31-dimethyl-1-oxacyclodotriaconta-3,5,7,9,11,29-hexaen-2-one
• CAS No.: 154396-73-3
• Molecular Formula: C₃₅H₅₆O₁₀
• Molecular Weight: 636.824
• DSSTox Substance ID: DTXSID10934983
• Mol file: 154396-73-3.mol

Synonyms:154396-73-3;32-ethyl-14,16,18,20,22,24,26,28-octahydroxy-15,31-dimethyl-1-oxacyclodotriaconta-3,5,7,9,11,29-hexaen-2-one;CID 3074004;DTXSID10934983

Chemical Property of 32-Ethyl-14,16,18,20,22,24,26,28-octahydroxy-15,31-dimethyl-1-oxacyclodotriaconta-3,5,7,9,11,29-hexaen-2-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 889.3 °C at 760 mmHg
• PKA: 14.06±0.70(Predicted)
• Flash Point: 272.6 °C
• PSA: 188.14000
• Density: 1.12 g/cm³
• LogP: 2.54910
• XLogP3: 4
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 1
• Exact Mass: 636.38734798
• Heavy Atom Count: 45
• Complexity: 987

Purity/Quality:

99% ^*data from raw suppliers

MYCOTICIN A 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1C(C=CC(CC(CC(CC(CC(CC(CC(C(C(CC=CC=CC=CC=CC=CC(=O)O1)O)C)O)O)O)O)O)O)O)C

Technology Process of 32-Ethyl-14,16,18,20,22,24,26,28-octahydroxy-15,31-dimethyl-1-oxacyclodotriaconta-3,5,7,9,11,29-hexaen-2-one

There total 13 articles about 32-Ethyl-14,16,18,20,22,24,26,28-octahydroxy-15,31-dimethyl-1-oxacyclodotriaconta-3,5,7,9,11,29-hexaen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C59H72O10 (858676-96-7) → RK-397 (154396-73-3)

Guidance literature:

With hydrogenchloride; In methanol; for 5h;

DOI:10.1021/ja052226d

Reference yield: 73.0%

C47H72O10 (676549-30-7) → RK-397 (154396-73-3)

Guidance literature:

With methanol; Dowex(R)50Wx₂ acidic resin;

DOI:10.1021/ja039618+

Reference yield:

C58H90O11Si → C35H56O10 + RK-397 (154396-73-3)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 24h;

DOI:10.1002/anie.200602601

upstream raw materials:

C₄₇H₇₂O₁₀

C₅₉H₇₂O₁₀

2-((2R,4R,6S)-6-(((4S,6S)-6-(((2R,4R,6S)-6-(((2R,4R,6R)-6-((E,3S,4S)-4-hydroxy-3,5-dimethylhex-1-enyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)acetaldehyde

{6-[6-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2-phenyl-[1,3]dioxan-4-yl}-acetaldehyde

Refernces

• 1、 Denmark, Scott E.,Fujimori, Shinji. "Total synthesis of RK-397". . p. 8971 - 8973. Retrieved 2007/10/03.