2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide

Base Information

• Chemical Name: 2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide
• CAS No.: 75136-79-7
• Molecular Formula: C₁₂H₁₄Cl₂N₂O₂
• Molecular Weight: 289.161
• Mol file: 75136-79-7.mol

Synonyms:2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide

Chemical Property of 2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide

There total 1 articles about 2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,6-dichloro-4-iodoaniline (697-89-2) + 9-methyl-9H-fluorene-9-carbonyl chloride (82102-37-2) + tert-butylamine (75-64-9) → 2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide (75136-79-7)

Guidance literature:

9-methyl-9H-fluorene-9-carbonyl chloride; With tri-tert-butyl phosphine; N-Methyldicyclohexylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; Inert atmosphere;

2,6-dichloro-4-iodoaniline; tert-butylamine; With 1,8-diazabicyclo[5.4.0]undec-7-ene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo3009337

Reference yield: 65.0%

2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide (75136-79-7) → clenbuterol (37148-27-9,50499-60-0)

Guidance literature:

2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide; With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 60 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1021/jo3009337

upstream raw materials:

2,6-dichloro-4-iodoaniline

9-methyl-9H-fluorene-9-carbonyl chloride

tert-butylamine

Downstream raw materials:

clenbuterol

Refernces