Technology Process of 4-bromo-1-chloro-2-(4-(2-cyclopropoxypropoxy)benzyl)benzene
There total 7 articles about 4-bromo-1-chloro-2-(4-(2-cyclopropoxypropoxy)benzyl)benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylsilane; trifluorormethanesulfonic acid; trifluoroacetic acid / 20 °C / Reflux
2.1: boron tribromide / dichloromethane / -78 - 20 °C
3.1: caesium carbonate / ISOPROPYLAMIDE / 80 °C
4.1: pyridinium p-toluenesulfonate / dichloromethane / 2 h / 20 °C
5.1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 0 °C
6.1: diethylzinc / dichloromethane / 0 °C / Inert atmosphere
6.2: 20 °C
With
triethylsilane; trifluorormethanesulfonic acid; trimethylsilyl trifluoromethanesulfonate; diethylzinc; pyridinium p-toluenesulfonate; boron tribromide; caesium carbonate; triethylamine; trifluoroacetic acid;
In
dichloromethane; ISOPROPYLAMIDE;
- Guidance literature:
-
diiodomethane;
With
diethylzinc;
In
dichloromethane;
at 0 ℃;
Inert atmosphere;
4-bromo-1-chloro-2-(4-(2-(vinyloxy)propoxy)benzyl)benzene;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C
2.1: aluminum (III) chloride / dichloromethane / -5 - 4 °C
3.1: triethylsilane; trifluorormethanesulfonic acid; trifluoroacetic acid / 20 °C / Reflux
4.1: boron tribromide / dichloromethane / -78 - 20 °C
5.1: caesium carbonate / ISOPROPYLAMIDE / 80 °C
6.1: pyridinium p-toluenesulfonate / dichloromethane / 2 h / 20 °C
7.1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 0 °C
8.1: diethylzinc / dichloromethane / 0 °C / Inert atmosphere
8.2: 20 °C
With
triethylsilane; aluminum (III) chloride; oxalyl dichloride; trifluorormethanesulfonic acid; trimethylsilyl trifluoromethanesulfonate; diethylzinc; pyridinium p-toluenesulfonate; boron tribromide; caesium carbonate; triethylamine; trifluoroacetic acid;
N,N-dimethyl-formamide;
In
dichloromethane; ISOPROPYLAMIDE;