ETHIRIMOL

Base Information

• Chemical Name: ETHIRIMOL
• CAS No.: 23947-60-6
• Molecular Formula: C11H19N3O
• Molecular Weight: 209.291
• Hs Code.: 2933599018
• Mol file: 23947-60-6.mol

Synonyms:4(1H)-Pyrimidinone,5-butyl-2-(ethylamino)-6-methyl- (9CI);5-Butyl-2-(ethylamino)-6-methyl-4(3H)pyrimidinone;5-Butyl-2-ethylamino-6-hydroxy-4-methylpyrimidine;ETH 560;Milgo;Milgo E;Milstem;Milstem Seed Dressing;NSC 263491;PP 149;

Chemical Property of ETHIRIMOL

Chemical Property:

• Appearance/Colour: White crystal
• Vapor Pressure: 0.000781mmHg at 25°C
• Melting Point: 159-160oC
• Refractive Index: 1.545
• Boiling Point: 306.2 °C at 760 mmHg
• PKA: 5
• Flash Point: 139 °C
• PSA: 58.04000
• Density: 1.1 g/cm³
• LogP: 2.33800
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Sparingly), Ethanol (Slightly), Methanol (Slightly)
• Water Solubility.: 253 mg l-1 (pH 5.2), 150 mg l-1 (pH 7.3), 153 mg l-1 (pH 9.3) at 20 °C

Purity/Quality:

Ethirimol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 21
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fungicide. Ethirimol is a systemic fungicide with both protective and curative actions. It controls mainly powdery mildew (Erysiphe gmminis) on barley, wheat and oats. Ethirimol can be applied as a seed dressing, as a foliar spray or directly to the soil in the root zone. Ethirimol is a pyrimidine based fungicide with wide applications such as controlling leaf spot of sugar beet.

Technology Process of ETHIRIMOL

There total 5 articles about ETHIRIMOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

monoethylguanidine sulphate (50693-82-8,3482-86-8) + ethyl 2-butylacetoacetate (1540-29-0) → ethirimol (23947-60-6)

Guidance literature:

monoethylguanidine sulphate; With sodium hydroxide; In methanol; at 35 ℃; for 2h;

ethyl 2-butylacetoacetate; With sulfuric acid; In cyclohexane; toluene; at 70 ℃;

Reference yield: 82.2%

ethyl guanidine (503-69-5) + methyl α-butylacetoacetate (32798-42-8) → ethirimol (23947-60-6)

Guidance literature:

at 120 ℃; for 0.0111111h;

Reference yield:

butyraldehyde (123-72-8) + 2-ethylamino-4-hydroxy-6-methylpyrimidine (5734-69-0) → ethirimol (23947-60-6)

Guidance literature:

palladium; In water; butan-1-ol;

upstream raw materials:

ethyl guanidine

ethyl 2-butylacetoacetate

butyraldehyde

2-ethylamino-4-hydroxy-6-methylpyrimidine

Downstream raw materials:

bupirimate

Refernces

• 1、 -. "Synthetic method of hydroxypyrimidine compound". Paragraph 0081-0083. . Retrieved 2020/12/08.
• 2、 -. "Preparation method of hydroxypyrimidine compound". Paragraph 0048-0050. . Retrieved 2019/10/01.