N²-benzyloxycarbonyl-N⁵-methyl-L-glutamine

Base Information

• Chemical Name: N²-benzyloxycarbonyl-N⁵-methyl-L-glutamine
• CAS No.: 95082-75-0
• Molecular Formula: C₁₄H₁₈N₂O₅
• Molecular Weight: 294.307
• Mol file: 95082-75-0.mol

Synonyms:N²-benzyloxycarbonyl-N⁵-methyl-L-glutamine

Chemical Property of N²-benzyloxycarbonyl-N⁵-methyl-L-glutamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-benzyloxycarbonyl-N⁵-methyl-L-glutamine

There total 2 articles about N²-benzyloxycarbonyl-N⁵-methyl-L-glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(benzyloxycarbonyl)-L-glutamic acid anhydride (4124-76-9) → N2-benzyloxycarbonyl-N5-methyl-L-glutamine (95082-75-0)

Guidance literature:

With ethanol; methylamine; benzene;

Reference yield:

N-benzyloxycarbonyl-L-glutamic acid (1155-62-0) + methylamine (74-89-5) → N1-methyl-N2-benzyloxycarbonyl-L-isoglutamine (87733-71-9) + N2-benzyloxycarbonyl-N5-methyl-L-glutamine (95082-75-0)

Guidance literature:

With triethylamine; isobutyl chloroformate; Multistep reaction. Title compound not separated from byproducts; 1.) THF, -20 deg C, 1 h, 2.) -20 deg C (30 min), -> room temperature (1 h);

Reference yield:

N2-benzyloxycarbonyl-N5-methyl-L-glutamine (95082-75-0) → N-(γ-glutamyl)methylamine (3081-62-7)

Guidance literature:

With palladium; Hydrogenation;

upstream raw materials:

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

N-benzyloxycarbonyl-L-glutamic acid

methylamine

Downstream raw materials:

N-(γ-glutamyl)methylamine

Refernces