N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

Base Information

• Chemical Name: N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride
• CAS No.: 1100292-18-9
• Molecular Formula: C₂₃H₂₄ClFN₄O₆S*ClH
• Molecular Weight: 575.445
• Mol file: 1100292-18-9.mol

Synonyms:N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

Chemical Property of N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

There total 12 articles about N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C39H38ClFN4O9S (1100292-32-7) → N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride (1100292-18-9)

Guidance literature:

C₃₉H₃₈ClFN₄O₉S; With trifluoroacetic acid; at 20 ℃;

With hydrogenchloride; In water; pH=3;

Reference yield:

2-fluro-4-iodoaniline (29632-74-4) → N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride (1100292-18-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium carbonate / dichloromethane; water / 144 h / Reflux

2.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 750.08 Torr

4.1: magnesium(II) perchlorate / acetonitrile / 15 h / 20 °C

5.1: dmap / propyl cyanide / 72 h / 70 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

6.2: 0.25 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / 20 °C

7.2: pH 3

With dmap; potassium phosphate; copper(l) iodide; magnesium(II) perchlorate; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In 1,4-dioxane; propyl cyanide; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

N,N-Dibenzyl-2-fluoro-4-iodoaniline (1093628-67-1) → N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride (1100292-18-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 750.08 Torr

3.1: magnesium(II) perchlorate / acetonitrile / 15 h / 20 °C

4.1: dmap / propyl cyanide / 72 h / 70 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

5.2: 0.25 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / 20 °C

6.2: pH 3

With dmap; potassium phosphate; copper(l) iodide; magnesium(II) perchlorate; hydrogen; sodium hydride; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In 1,4-dioxane; propyl cyanide; ethanol; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

C₃₉H₃₈ClFN₄O₉S

2-fluro-4-iodoaniline

5-chlorothiophene-2-carbonyl chloride

4-(4-amino-3-fluoro-phenyl)-morpholin-3-one

Refernces

• 1、 -. "AMINOACYL PRODRUGS". Page/Page column 12. . Retrieved 2010/12/26.