Technology Process of (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-2-(cyclopropylmethyl)-6,6,6-trifluoro-3-(((S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)hexanamido)thio)propanoate
There total 18 articles about (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-2-(cyclopropylmethyl)-6,6,6-trifluoro-3-(((S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)hexanamido)thio)propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N,N'-bis(tert-butoxy)carbonyl-L-cystine dimethyl ester;
With
silver nitrate;
In
methanol;
for 0.5h;
(2R,3S)-3-(cyclopropylmethyl)-N-((3S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide;
With
triethylamine;
In
methanol;
at 20 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C
1.2: 20 °C
2.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C
3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1.5 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 1.83 h / 20 °C
4.2: 8 - 20 °C
4.3: Lux-Cell4 / 40 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
5.1: silver nitrate / methanol / 0.5 h
5.2: 48 h / 20 °C
With
oxalyl dichloride; hydrogen bromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; silver nitrate; acetic acid; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hexacyanoferrate(II); sodium hydrogencarbonate; sodium hydroxide / N,N-dimethyl-formamide; water / 1.67 h / 110 - 120 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C
2.2: 20 °C
3.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C
4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1.5 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 1.83 h / 20 °C
5.2: 8 - 20 °C
5.3: Lux-Cell4 / 40 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
6.1: silver nitrate / methanol / 0.5 h
6.2: 48 h / 20 °C
With
potassium hexacyanoferrate(II); oxalyl dichloride; hydrogen bromide; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; silver nitrate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
