4-(pyridine-3-carbonyloxy)butyl pyridine-3-carboxylate

Base Information

• Chemical Name: 4-(pyridine-3-carbonyloxy)butyl pyridine-3-carboxylate
• CAS No.: 101952-76-5
• Molecular Formula: C₁₆H₁₆N₂O₄
• Molecular Weight: 300.314
• Mol file: 101952-76-5.mol

Synonyms:1,4-Butanedioldinicotinate

Chemical Property of 4-(pyridine-3-carbonyloxy)butyl pyridine-3-carboxylate

Chemical Property:

• Vapor Pressure: 2.87E-08mmHg at 25°C
• Boiling Point: 449.4°Cat760mmHg
• Flash Point: 225.6°C
• PSA: 78.38000
• Density: 1.222g/cm³
• LogP: 2.27060

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(pyridine-3-carbonyloxy)butyl pyridine-3-carboxylate

There total 5 articles about 4-(pyridine-3-carbonyloxy)butyl pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ O,O'-bisnicotinoyl-1,4-butylenediol (101952-76-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 18.5h; Inert atmosphere;

Reference yield: 78.0%

1,4-dibromo-butane (110-52-1) + sodium nicotinate (54-86-4) → O,O'-bisnicotinoyl-1,4-butylenediol (101952-76-5)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1134/S1070363214040252

Reference yield:

1,4-dibromo-butane (110-52-1) + nicotinic acid (59-67-6) → O,O'-bisnicotinoyl-1,4-butylenediol (101952-76-5)

Guidance literature:

nicotinic acid; With potassium carbonate; In water; Green chemistry;

1,4-dibromo-butane; With tetrabutylammomium bromide; at 110 ℃; for 3h; Sealed tube; Green chemistry;

DOI:10.1039/d1ra04814g

upstream raw materials:

3-pyridinecarbonyl chloride

Butane-1,4-diol

1,4-dibromo-butane

sodium nicotinate

Refernces

• 1、 Bai, Lin,Ding, Shenglong,Ma, Xiaofang. "Solvent-free synthesis of symmetric methylene diestersviadirect reaction of aromatic carboxylates with 1,n-dihaloalkanes". . p. 28711 - 28715. Retrieved 2021/09/22.