Technology Process of (3S,4S,2'R,1Z)-3-(1-hexenyl)-4-(2'-phenylmethyloxy-tridecyl)-2-oxetanone
There total 8 articles about (3S,4S,2'R,1Z)-3-(1-hexenyl)-4-(2'-phenylmethyloxy-tridecyl)-2-oxetanone which
guide to synthetic route it.
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synthetic route:
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244628-34-0
(2S,3S,3aS,4aS,5R,8S,8aR,2'R)-2-(2'-phenylmethyloxy-tridecyl)-5,10,10-trimethyl-5,8-methano-octahydro-2H-isoxazolo-[3,2-b]benzoxazole-3-carboxylic acid ethyl ester
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: 76 percent / DIBAH / toluene / 1 h / -78 °C
2.1: sodium amide / tetrahydrofuran / 4 h / Heating
2.2: tetrahydrofuran / -78 °C
3.1: mCPBA / diethyl ether / 1 h / 20 °C
3.2: aq. HCl / tetrahydrofuran / 2 h / 20 °C
4.1: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 24 h / 20 °C
5.1: 1.13 g / PhSO2Cl; pyridine
With
pyridine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diisobutylaluminium hydride; sodium amide; benzenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; toluene; tert-butyl alcohol;
DOI:10.1021/ol990734k
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244628-35-1
(2S,3S,3aS,4aS,5R,8S,8aR,2'R)-2-(2'-phenylmethyloxy-tridecyl)-5,10,10-trimethyl-5,8-methano-octahydro-2H-isoxazolo-[3,2-b]-benzoxazole-3-carboxaldehyde
- Guidance literature:
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Multi-step reaction with 4 steps
1.1: sodium amide / tetrahydrofuran / 4 h / Heating
1.2: tetrahydrofuran / -78 °C
2.1: mCPBA / diethyl ether / 1 h / 20 °C
2.2: aq. HCl / tetrahydrofuran / 2 h / 20 °C
3.1: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 24 h / 20 °C
4.1: 1.13 g / PhSO2Cl; pyridine
With
pyridine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium amide; benzenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; tert-butyl alcohol;
DOI:10.1021/ol990734k
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: 170 mg / 4 Angstroem molecular sieves; N-methylmorpholine N-oxide; TPAP / CH2Cl2 / 1 h / 20 °C
2.1: sodium amide / tetrahydrofuran / 4 h / Heating
2.2: tetrahydrofuran / -78 °C
3.1: mCPBA / diethyl ether / 1 h / 20 °C
3.2: aq. HCl / tetrahydrofuran / 2 h / 20 °C
4.1: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 24 h / 20 °C
5.1: 1.13 g / PhSO2Cl; pyridine
With
pyridine; sodium chlorite; sodium dihydrogenphosphate; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; sodium amide; 4-methylmorpholine N-oxide; benzenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol990734k