DIMETHIRIMOL

Base Information

• Chemical Name: DIMETHIRIMOL
• CAS No.: 5221-53-4
• Molecular Formula: C11H19 N3 O
• Molecular Weight: 209.291
• Hs Code.: 2933599018
• Mol file: 5221-53-4.mol

Synonyms:4(1H)-Pyrimidinone,5-butyl-2-(dimethylamino)-6-methyl- (9CI); 4-Pyrimidinol,5-butyl-2-(dimethylamino)-6-methyl- (7CI,8CI);2-Dimethylamino-6-hydroxy-4-methyl-5-butylpyrimidine;5-Butyl-2-dimethylamino-4-hydroxy-6-methylpyrimidine; Dimethirimol;Dimethyrimol; Melkeb; Methyrimol; Milcurb; NSC 263490; PP 675

Chemical Property of DIMETHIRIMOL

Chemical Property:

• Vapor Pressure: 0.00147mmHg at 25°C
• Melting Point: 103℃
• Refractive Index: 1.5700 (estimate)
• Boiling Point: 296.1°Cat760mmHg
• PKA: 5
• Flash Point: 132.9°C
• PSA: 49.25000
• Density: 1.07g/cm³
• LogP: 1.89920
• Storage Temp.: 0-6°C
• Water Solubility.: 1.2 g l-1 (25 °C)

Purity/Quality:

99%, ^*data from raw suppliers

Dimethrimol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 21-52
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fungicide. Dimethirimol is a systemic fungicide that provides both protective and curative control of powdery mildew (Sphaeratheca fulginea) in cucurbits. Other uses include tobacco, tomatoes and ornamentals. Dimethrimolis a fungicide used initially to prevent powdery mildew and other fungal infections or crops. Pesticide.

Technology Process of DIMETHIRIMOL

There total 2 articles about DIMETHIRIMOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

methyl α-butylacetoacetate (32798-42-8) + 1,1-dimethylguanidine dihydrogensulfate (311-77-3,1186-46-5) → 5-butyl-2-dimethylamino-4-hydroxy-6-methyl pyrimidine (5221-53-4)

Guidance literature:

1,1-dimethylguanidine dihydrogensulfate; With sodium hydroxide; In methanol; at 60 ℃; for 1h;

methyl α-butylacetoacetate; In methanol; at 105 ℃; Temperature; Inert atmosphere; Dean-Stark;

Reference yield:

→ 5-butyl-2-dimethylamino-4-hydroxy-6-methyl pyrimidine (5221-53-4)

Guidance literature:

N,N-Dimethylguanidinsulfat, α-n-Butylacetessigesterethylester;

DOI:10.1038/2191160a0

Reference yield:

5-butyl-2-dimethylamino-4-hydroxy-6-methyl pyrimidine (5221-53-4) → potassium salt of 2-dimethylamino-4-methyl-5-n-butyl-6-hydroxypyrimidine (28216-95-7)

Guidance literature:

With potassium hydroxide; In ethanol;

upstream raw materials:

methyl α-butylacetoacetate

1,1-dimethylguanidine dihydrogensulfate

Downstream raw materials:

potassium salt of 2-dimethylamino-4-methyl-5-n-butyl-6-hydroxypyrimidine

sodium salt of 2-dimethylamino-4-methyl-5-n-butyl-6-hydroxypyrimidine

Refernces

• 1、 -. "Synthetic method of hydroxypyrimidine compound". Paragraph 0048-0074. . Retrieved 2020/12/08.
• 2、 -. "2-(Pyrazolyloxy) -pyridin-3-ylacetic acid derivatives, agents containing the same and use thereof against noxious fungi and animal parasites". . . Retrieved 2008/06/13.