Technology Process of 3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine
There total 7 articles about 3-(benzylsulfonyl)-N-[(1R)-3-cyclopropyl-1-(4-fluorophenyl)-1-(trifluoromethyl)prop-2-yn-1-yl]-L-alanine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Oxone;
In
water; acetone;
for 0.75h;
- Guidance literature:
-
C23H21F4NOS;
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;
In
water; tert-butyl alcohol;
for 4.5h;
With
sodium hydroxide;
In
water;
Alkaline aqueous solution;
With
hydrogenchloride;
In
water;
pH=4;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridinium p-toluenesulfonate; toluene-4-sulfonic acid / toluene / 72 h / Heating / reflux
2.1: n-butyllithium / tetrahydrofuran; hexanes; toluene / 0.25 h / -78 - 0 °C
2.2: 3 h / -78 - 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
3.2: 0.33 h / -78 - 20 °C
4.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 4.5 h
4.2: Alkaline aqueous solution
4.3: pH 4
With
sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide;
pyridinium p-toluenesulfonate; toluene-4-sulfonic acid;
In
tetrahydrofuran; hexanes; dichloromethane; water; toluene; tert-butyl alcohol;