Ethyl 6-quinolyl ether

Base Information

• Chemical Name: Ethyl 6-quinolyl ether
• CAS No.: 22883-85-8
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933499090
• European Community (EC) Number: 245-290-1
• UNII: UEV83W8FHE
• DSSTox Substance ID: DTXSID60177424
• Nikkaji Number: J286.340E
• Wikidata: Q83047752
• Mol file: 22883-85-8.mol

Synonyms:6-ethoxyquinoline;Ethyl 6-quinolyl ether;22883-85-8;UEV83W8FHE;EINECS 245-290-1;Quinoline, 6-ethoxy-;UNII-UEV83W8FHE;SCHEMBL826938;DTXSID60177424

Chemical Property of Ethyl 6-quinolyl ether

Chemical Property:

• Vapor Pressure: 0.00286mmHg at 25°C
• Boiling Point: 294.4°Cat760mmHg
• Flash Point: 108°C
• PSA: 22.12000
• Density: 1.101g/cm³
• LogP: 2.63350
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

6-ethoxy-Quinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC2=C(C=C1)N=CC=C2

Technology Process of Ethyl 6-quinolyl ether

There total 4 articles about Ethyl 6-quinolyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Ethoxyaniline (156-43-4) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 6-ethoxy-quinoline (22883-85-8)

Guidance literature:

With sulfuric acid; 2-hydroxynitrobenzene; at 160 ℃;

Reference yield:

4-ethoxyacetanilide (62-44-2,105931-34-8) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 6-ethoxy-quinoline (22883-85-8)

Guidance literature:

With sulfuric acid; orthoarsenic acid; at 150 ℃;

Reference yield:

4-Ethoxyaniline (156-43-4) + 1-ethoxy-4-nitrobenzene (100-29-8) → 6-ethoxy-quinoline (22883-85-8)

Guidance literature:

With sulfuric acid; glycerol;

upstream raw materials:

4-Ethoxyaniline

glycerol

1-ethoxy-4-nitrobenzene

4-ethoxyacetanilide

Downstream raw materials:

6-hydroxy-5-nitroquinoline

6-ethoxy-5-bromo-quinoline

6-hydroxyquinoline

6-ethoxy-1-benzoyl-1,2-dihydro-quinoline-2-carbonitrile

Refernces

• 1、 -. "New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase". . . Retrieved 2008/06/13.