Succinylsulfathiazole

Base Information

• Chemical Name: Succinylsulfathiazole
• CAS No.: 116-43-8
• Deprecated CAS: 1391-00-0
• Molecular Formula: C13H13 N3 O5 S2
• Molecular Weight: 355.395
• Hs Code.: 29350090
• European Community (EC) Number: 204-141-0
• NSC Number: 758161,163939,14193
• UNII: RSS8647O4S
• DSSTox Substance ID: DTXSID7045281
• Nikkaji Number: J5.280I
• Wikipedia: Succinylsulfathiazole
• Wikidata: Q3976577
• NCI Thesaurus Code: C152443
• Metabolomics Workbench ID: 67497
• ChEMBL ID: CHEMBL1484857
• Mol file: 116-43-8.mol

Synonyms:4'-(2-thiazolylsulfamoyl)succinanilic acid;succinylsulfathiazole;succinylsulfathiazole monohydrate;sulfasuccithiazole

Chemical Property of Succinylsulfathiazole

Chemical Property:

• Melting Point: 187 - 193oC
• Refractive Index: 1.6390 (estimate)
• PKA: pKa 4.5 (Uncertain)
• PSA: 162.08000
• Density: 1.601g/cm3
• LogP: 2.97400
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: 1 M NaOH: soluble50mg/mL
• Water Solubility.: 0.49g/L(38 oC)
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 355.02966287
• Heavy Atom Count: 23
• Complexity: 526

Purity/Quality:

99% ^*data from raw suppliers

Sst ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC(=O)CCC(=O)O)S(=O)(=O)NC2=NC=CS2
• Uses: Succinylsulfathiazole is antibacterial Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid. Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.
• Therapeutic Function: Antibacterial (intestinal)

Technology Process of Succinylsulfathiazole

There total 8 articles about Succinylsulfathiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

succinic acid anhydride (108-30-5) + Sulfathiazole (72-14-0) → succinylsulfathiazole (116-43-8)

Guidance literature:

In acetone;

DOI:10.1007/BF02464305

Reference yield:

succinylsulfathiazole, 1-butanol solvate → succinylsulfathiazole (116-43-8) + butan-1-ol (71-36-3)

Guidance literature:

at 30 - 250 ℃; Thermodynamic data; E_a for desolvation;

DOI:10.1002/jps.2600830626

Reference yield:

succinylsulfathiazole, 1-pentanol solvate → pentan-1-ol (71-41-0) + succinylsulfathiazole (116-43-8)

Guidance literature:

at 30 - 250 ℃; Thermodynamic data; E_a for desolvation;

DOI:10.1002/jps.2600830626

upstream raw materials:

2-thiazolylamine

N-(4-chlorosulfonyl-phenyl)-succinamic acid

succinic acid anhydride

Sulfathiazole

Downstream raw materials:

N-[4-(3-xanthen-9-yl-3H-thiazol-2-ylidenesulfamoyl)-phenyl]-succinamic acid

indan-1,2,3-trione hydrate

C₁₇H₁₆N₄O₇S₂

N,N-succinyl-sulfanilic acid thiazol-2-ylamide

Refernces

• 1、 -. "Methods and compositions for diagnostic and therapeutic targeting of COX-2". Page/Page column 45. . Retrieved 2008/06/13.
• 2、 -. "Process for formulating a synthetic drug for use in animal feed, and resulting formulation". . . Retrieved 2008/06/13.