(R)-naproxen methyl ester

Base Information

• Chemical Name: (R)-naproxen methyl ester
• CAS No.: 81623-44-1
• Molecular Formula: C₁₅H₁₆O₃
• Molecular Weight: 244.29
• Mol file: 81623-44-1.mol

Synonyms:(R)-naproxen methyl ester

Chemical Property of (R)-naproxen methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-naproxen methyl ester

There total 12 articles about (R)-naproxen methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

naproxen (23981-80-8) + carbonic acid dimethyl ester (616-38-6) → (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-naproxen methyl ester (81623-44-1) + (S)-naproxen methyl ester (26159-35-3)

Guidance literature:

With Novozym 435; In acetonitrile; at 45 ℃; for 216h; optical yield given as %ee; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.molcatb.2010.01.014

Reference yield:

methyl 2-(6-methoxy-2-naphthyl)propionate (30012-51-2) → (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-naproxen methyl ester (81623-44-1)

Guidance literature:

With Sporopollenin-gel encapsulated Candida rugosa lipase; In 2,2,4-trimethylpentane; at 30 ℃; for 24h; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1016/j.molcatb.2009.10.003

Reference yield:

(R,S) naproxen ethyl ester (31220-35-6,84890-24-4,84890-25-5,37961-57-2) → (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-naproxen methyl ester (81623-44-1)

Guidance literature:

With Candida rugose lipase CRL₁ 10X; In decane; at 20 ℃; for 100h; enantioselective reaction; Kinetics; Enzymatic reaction;

DOI:10.1016/j.tetasy.2017.01.014

upstream raw materials:

methanol

(R)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid (3aR,5R,6S,6aR)-5-(1,2-dihydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

methyl 2-(6-methoxy-2-naphthyl)propionate

naproxen

Downstream raw materials:

(R)-2-(6-methoxy-2-naphthyl)propionic acid

Refernces

• 1、 Ozyilmaz, Elif,Bayrakci, Mevlut,Yilmaz, Mustafa. "Improvement of catalytic activity of Candida rugosa lipase in the presence of calix[4]arene bearing iminodicarboxylic/phosphonic acid complexes modified iron oxide nanoparticles". . p. 1 - 8. Retrieved 2015/12/18.
• 2、 Sayin, Serkan,Yilmaz, Elif,Yilmaz, Mustafa. "Improvement of catalytic properties of Candida Rugosa lipase by sol-gel encapsulation in the presence of magnetic calix[4]arene nanoparticles". experimental part. p. 4021 - 4024. Retrieved 2011/07/29.