Triethylene glycol monododecyl ether

Base Information

• Chemical Name: Triethylene glycol monododecyl ether
• CAS No.: 3055-94-5
• Molecular Formula: C18H38 O4
• Molecular Weight: 318.497
• Hs Code.: 2909499000
• European Community (EC) Number: 221-280-2
• UNII: F32E4CB0UJ
• DSSTox Substance ID: DTXSID6058631
• Nikkaji Number: J78.124J
• Wikidata: Q27277561
• RXCUI: 1310570
• ChEMBL ID: CHEMBL1651993
• Mol file: 3055-94-5.mol

Synonyms:laureth-3 oxyethylene ether;Lauryl triethoxylate

Chemical Property of Triethylene glycol monododecyl ether

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 1.66E-08mmHg at 25°C
• Melting Point: 16.5-17.0 °C
• Refractive Index: n20/D 1.451
• Boiling Point: 412 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 202.9 °C
• PSA: 47.92000
• Density: 0.93 g/cm³
• LogP: 3.94940
• Storage Temp.: 2-8°C
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 19
• Exact Mass: 318.27700969
• Heavy Atom Count: 22
• Complexity: 188

Purity/Quality:

98% ^*data from raw suppliers

TriethyleneglycolMonolaurylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCCCCOCCOCCOCCO
• Uses: Triethyleneglycol monododecyl ether is a surfactant, detergent, and emulsifier used in cosmetic preparations. Triethyleneglycol Monolauryl Ether is used as a reagent in the synthesis of N,N-dimethyl-N-dodecyl polyoxyethylene amine-based surfactants. It is also used as a reagent in the synthesis of hybrid carbohydrate/oligoethylene oxide surfactants.

Technology Process of Triethylene glycol monododecyl ether

There total 8 articles about Triethylene glycol monododecyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-dodecyl alcohol (112-53-8) + C6H12O6S → 2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol (3055-94-5,9015-55-8)

Guidance literature:

1-dodecyl alcohol; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h; Inert atmosphere;

C₆H₁₂O₆S; In tetrahydrofuran; mineral oil; Inert atmosphere;

With sulfuric acid; In tetrahydrofuran; water; mineral oil; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.molpharmaceut.7b00496

Reference yield: 61.0%

1-dodecylbromide (143-15-7) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol (3055-94-5,9015-55-8)

Guidance literature:

With sodium hydride; at 100 ℃; for 48h; Inert atmosphere;

DOI:10.1007/s11743-013-1540-7

Reference yield: 48.0%

Iododecane (2050-77-3) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol (3055-94-5,9015-55-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 2h; Inert atmosphere;

upstream raw materials:

oxirane

diethylene glycol monododecyl ether

1-dodecylbromide

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

tetraethylene glycol monododecyl ether

pentaethylene glycol mono-n-dodecyl ether

Hexaethylene glycol monododecyl ether

polidocanol

Refernces

• 1、 -. "Polyoxyethylene ether carboxylic acid dimeric surfactant type drag reducer as well as preparation method and application thereof". Paragraph 0096-0098; 0123-0125; 0150-0152. . Retrieved 2019/09/13.
• 2、 -. "Preparation method and application of monodisperse nonapolyethylene glycol dodecyl alcohol monoether and sulphate thereof". Paragraph 0026; 0028; 0029. . Retrieved 2017/08/27.