DEA NONOATE

Base Information

• Chemical Name: DEA NONOATE
• CAS No.: 138475-09-9
• Molecular Formula: C4H10N3O2-
• Molecular Weight: 155.132
• Mol file: 138475-09-9.mol

Synonyms:2-(N,N-Diethylamino)-diazenolate 2-oxide sodium salt hydrate;1,1-Diethyl-2-hydroxy-2-nitrosohydrazine sodium salt;Diethylamine/nitric oxide complex sodium salt hydrate;sodium 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate;DEA NONOate sodium salt hydrate;diethylamine-nitric oxide complex sodium salt;Diethylamine NONOate sodium salt hydrate;diethylamine-NO;sodium N,N-(diethylamino)diazen-1-ium-1,2-diolate;

Chemical Property of DEA NONOATE

Chemical Property:

• Vapor Pressure: 0.25mmHg at 25°C
• Melting Point: 196-200oC
• Boiling Point: 181.4°C at 760 mmHg
• Flash Point: 63.5°C
• PSA: 58.97000
• LogP: 0.72440
• Storage Temp.: Freezer (-20°C)

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DEA NONOATE

There total 2 articles about DEA NONOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

diethylamine (109-89-7) → sodium N,N-(diethylamino)diazen-1-ium-1,2-diolate (138475-09-9)

Guidance literature:

With nitrogen(II) oxide; sodium methylate; In methanol; diethyl ether; at 20 ℃; for 24h; under 2068.65 Torr;

Reference yield: 37.0%

→ sodium N,N-(diethylamino)diazen-1-ium-1,2-diolate (138475-09-9)

Guidance literature:

With sodium methylate; In methanol; diethyl ether;

With nitrogen(II) oxide; In methanol; diethyl ether; at 25 ℃; for 48h; under 3800.26 Torr;

Reference yield: 91.0%

O2-(2,4-dinitro-5-fluorophenyl) 1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate (903568-91-2) + sodium N,N-(diethylamino)diazen-1-ium-1,2-diolate (138475-09-9) → 1-[1-(N,N-dimethylamino)diazen-1-ium-1,2-diol-2-ato]-2,4-dinitro-5-[1-(N,N-diethylamino)diazen-1-ium-1,2-diol-2-ato]benzene (1093077-91-8)

Guidance literature:

In acetone; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm800831y

upstream raw materials:

diethylamine

Downstream raw materials:

1-((2-Hydroxycyclohexyl)oxy)-2-oxo-3,3-diethyl-1-triazene

1-n-Propoxy-2-oxo-3,3-diethyl-1-triazene

O⁽²⁾-((5-nitro-2-(tetrahydropyran-2-yloxy)phenyl)methyl)-1-( N,N-diethylamino)diazen-1-ium-1,2-diolate

tetrahydro-2H-2-pyranol

Refernces

• 1、 Lv, Tian,Wu, Jianbing,Kang, Fenghua,Wang, Tingting,Wan, Boheng,Lu, Jin-Jian,Zhang, Yihua,Huang, Zhangjian. "Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells". . p. 2164 - 2167. Retrieved 2018.
• 2、 Kang, Fenghua,Zhu, Jiayi,Wu, Jianbing,Lv, Tian,Xiang, Hua,Tian, Jide,Zhang, Yihua,Huang, Zhangjian. "O 2-3-Aminopropyl diazeniumdiolates suppress the progression of highly metastatic triple-negative breast cancer by inhibition of microvesicle formation via nitric oxide-based epigenetic regulation". . p. 6893 - 6898. Retrieved 2018/09/11.
• 3、 -. "COMPOSITIONS AND METHODS OF DIAZENIUMDIOLATE-BASED PRODRUGS FOR TREATING CANCER". Page/Page column 58. . Retrieved 2016/07/27.