3-methyl-2-phenyl-1-pyrroline

Base Information

• Chemical Name: 3-methyl-2-phenyl-1-pyrroline
• CAS No.: 152711-43-8
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.231
• Mol file: 152711-43-8.mol

Synonyms:3-methyl-2-phenyl-1-pyrroline

Chemical Property of 3-methyl-2-phenyl-1-pyrroline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-2-phenyl-1-pyrroline

There total 6 articles about 3-methyl-2-phenyl-1-pyrroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

→ 3-methyl-2-phenyl-1-pyrroline (152711-43-8)

Guidance literature:

With [(bis(2-dicyclohexylphosphinoethyl)amine)Fe(CO)Br₂]; sodium triethylborate; potassium tert-butylate; In toluene; at 120 ℃; for 12h; Inert atmosphere;

Reference yield: 55.0%

2-phenyl-1-pyrroline (700-91-4) → 3-methyl-2-phenyl-1-pyrroline (152711-43-8)

Guidance literature:

With lithium diisopropyl amide; at 0 ℃;

DOI:10.1016/S0040-4039(00)73710-5

Reference yield:

3-Benzoyl-3-methyl-1-vinyl-pyrrolidin-2-one (152711-37-0) → 3-methyl-2-phenyl-1-pyrroline (152711-43-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 24h; Yield given; Heating;

upstream raw materials:

3-Benzoyl-3-methyl-1-vinyl-pyrrolidin-2-one

2-phenyl-1-pyrroline

3-benzoyl-N-vinylpyrrolidin-2-one

benzoic acid ethyl ester

Downstream raw materials:

(2R,3R)-3-Methyl-2-phenyl-pyrrolidine

cis-2-phenyl-3-methylpyrrolidine

Refernces

• 1、 Sorgi, Kirk L.,Maryanoff, Cynthia A.,McComsey, David F.,Maryanoff, Bruce E.,Deur, Christopher,Hegedus, Louis S.. "N-vinylpyrrolidin-2-one as a 3-aminopropyl carbanion equivalent in the synthesis of substituted 1-pyrrolines: 2-phenyl-1-pyrroline: [ 2H-Pyrrole, 3,4-dihydro-5-phenyl- ]". . p. 215 - 215. Retrieved 2017/10/05.
• 2、 Pal, Kollol,Behnke, Mark L.,Tong, Liang. "A General Stereocontrolled Synthesis of cis-2,3 Disubstituted Pyrrolidines and Piperidines". . p. 6205 - 6208. Retrieved 2007/10/02.