Technology Process of (S)-2,6-Bis-(2,2,2-trifluoro-acetylamino)-hexanoic acid [2-(4-vinyl-benzylcarbamoyl)-ethyl]-amide
There total 3 articles about (S)-2,6-Bis-(2,2,2-trifluoro-acetylamino)-hexanoic acid [2-(4-vinyl-benzylcarbamoyl)-ethyl]-amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
1-methyl-pyrrolidin-2-one;
at 20 ℃;
for 16h;
DOI:10.1021/ma047621n
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
2: 98 percent / O-benzotriazole-N,N,N',N'-tetramethyluronium PF6; N-hydroxybenzotriazole; N,N-diisopropylethylamine / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/ma047621n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / O-benzotriazole-N,N,N',N'-tetramethyluronium PF6; N-hydroxybenzotriazole; N,N-diisopropylethylamine / dimethylformamide / 16 h / 20 °C
2: 99 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
3: 98 percent / O-benzotriazole-N,N,N',N'-tetramethyluronium PF6; N-hydroxybenzotriazole; N,N-diisopropylethylamine / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ma047621n