N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester

Base Information

• Chemical Name: N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester
• CAS No.: 1099718-55-4
• Molecular Formula: C₂₅H₂₄NO₈P
• Molecular Weight: 497.441
• Mol file: 1099718-55-4.mol

Synonyms:N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester

Chemical Property of N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester

There total 2 articles about N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.3%

N-(fluorenyl-9-methoxycarbonyl)-L-tyrosine methyl ester (82911-79-3) → N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester (1099718-55-4)

Guidance literature:

With 4-methyl-morpholine; trichlorophosphate; In dichloromethane; for 7h;

DOI:10.1002/chem.200801046

Reference yield:

methanol (67-56-1) + Fmoc-L-Tyr(PO(OEt)2)-OMe (1182718-01-9) → N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester (1099718-55-4)

Guidance literature:

Fmoc-L-Tyr(PO(OEt)2)-OMe; With trimethylsilyl bromide; In dichloromethane; at 25 ℃; for 24h;

methanol; for 2h;

DOI:10.1021/ja9042142

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-O'-phosphonotyrosine methyl ester (1099718-55-4) → N-Fmoc-Tyr-OH (112883-29-1,92954-90-0)

Guidance literature:

With alkaline phosphatase from bovine intestinal mucosa; Fmoc-GFF_pYGH_pY; water; In aq. phosphate buffer; Flow reactor; Enzymatic reaction;

upstream raw materials:

N-(fluorenyl-9-methoxycarbonyl)-L-tyrosine methyl ester

methanol

Fmoc-L-Tyr(PO(OEt)2)-OMe

Downstream raw materials:

N-(fluorenyl-9-methoxycarbonyl)-L-tyrosine methyl ester

N-Fmoc-Tyr-OH

Refernces

• 1、 Emgenbroich, Marco,Borrelli, Cristiana,Shinde, Sudhirkumar,Lazraq, Issam,Vilela, Filipe,Hall, Andrew J.,Oxelbark, Joakim,De Lorenzi, Ersilia,Courtois, Julien,Simanova, Anna,Verhage, Jeroen,Irgum, Knut,Karim, Kai,Sellergren, Boerje. "A phosphotyrosine-imprinted polymer receptor for the recognition of tyrosine phosphorylated peptides". experimental part. p. 9516 - 9529. Retrieved 2009/11/30.