Z-L-theanine

Base Information

• Chemical Name: Z-L-theanine
• CAS No.: 95082-77-2
• Molecular Formula: C₁₅H₂₀N₂O₅
• Molecular Weight: 308.334
• Mol file: 95082-77-2.mol

Synonyms:Z-L-theanine

Chemical Property of Z-L-theanine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Z-L-Gln(Et)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-L-theanine

There total 4 articles about Z-L-theanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester (4652-65-7) + ethylamine (75-04-7,85404-22-4) → Z-L-theanine (95082-77-2)

Guidance literature:

In tetrahydrofuran; at 80 ℃; for 4h; Microwave irradiation;

DOI:10.1021/acschemneuro.7b00036

Reference yield:

N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid (5680-86-4) + ethylamine (75-04-7,85404-22-4) → Z-L-theanine (95082-77-2)

Guidance literature:

In tetrahydrofuran; at 80 ℃; for 4h; Microwave irradiation;

DOI:10.1021/acschemneuro.7b00036

Reference yield:

(S)-2-(benzyloxycarbonylamino)-5-ethoxy-5-oxopentanoic acid (35726-62-6,1029401-62-4) → Z-L-theanine (95082-77-2)

Guidance literature:

With ethylamine;

upstream raw materials:

(S)-2-(benzyloxycarbonylamino)-5-ethoxy-5-oxopentanoic acid

N-benzyloxycarbonyl-L-glutamic acid

ethylamine

(S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester

Downstream raw materials:

N-ethyl-L-glutamine

Refernces

• 1、 Antonjuk, David J.,Boadle, Deborah K.,Cheung, H.T.Andrew,Tran, Trung Q.. "Synthesis of Monoamides of Methotrexate from L-Glutamic Acid Monoamide t-Butyl Esters". . p. 1989 - 2004. Retrieved 2007/10/02.