BENZYL 2-BROMOETHYL ETHER

Base Information

• Chemical Name: BENZYL 2-BROMOETHYL ETHER
• CAS No.: 1462-37-9
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Hs Code.: 29093090
• Mol file: 1462-37-9.mol

Synonyms:Ether,benzyl 2-bromoethyl (7CI,8CI);1-(Benzyloxy)-2-bromoethane;1-[(2-Bromoethoxy)methyl]benzene;2-(Benzyloxy)-1-bromoethane;2-(Benzyloxy)ethyl bromide;2-Bromoethyl benzyl ether;2-Bromoethylphenylmethyl ether;[(2-Bromoethoxy)methyl]benzene;1-bromo-2-benzyloxyethane;

Chemical Property of BENZYL 2-BROMOETHYL ETHER

Chemical Property:

• Appearance/Colour: Clear colorless to pale yellow liquid
• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: n20/D 1.541(lit.)
• Boiling Point: 258.6 °C at 760 mmHg
• Flash Point: 111.7 °C
• PSA: 9.23000
• Density: 1.358 g/cm³
• LogP: 2.59810
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Water Solubility.: Slightly soluble in water

Purity/Quality:

97% Min ^*data from raw suppliers

[(2-Bromoethyloxy)methyl]benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Alkylation reagent for synthesis of a macrocyclic antifungal antibiotic.1 Benzyl 2-broMoethyl ether is a reactant used in the preparation of muscarinic antagonist. Building block used to prepare a copper phthalocyanine discotic liquid crystal.

Technology Process of BENZYL 2-BROMOETHYL ETHER

There total 17 articles about BENZYL 2-BROMOETHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,4,6-tris(benzyloxy)-1,3,5-triazine (7285-83-8) + 2-bromoethanol (540-51-2) → bromoethyl-2-benzyl ether (1462-37-9)

Guidance literature:

With trifluorormethanesulfonic acid; In 1,4-dioxane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ol302222p DOI:10.1021/ol302222p

Reference yield: 98.0%

2-bromoethanol (540-51-2) + benzyl alcohol (100-51-6,185532-71-2) → bromoethyl-2-benzyl ether (1462-37-9)

Guidance literature:

With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I); at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/adsc.201401097

Reference yield: 98.0%

2-Benzyloxyethanol (622-08-2,1201808-31-2) → bromoethyl-2-benzyl ether (1462-37-9)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jal086112

upstream raw materials:

oxirane

benzyl bromide

1-bromo-2-(chloromethoxy)ethane

2-Benzyloxyethanol

Downstream raw materials:

4-acetonyl-1-<2-(benzyloxy)ethyl>piperidine

diethyl acetoxy(2-benzyloxyethyl)malonate

[1-[1-(2-Benzyloxy-ethyl)-1,3-dihydro-isoindol-2-yl]-meth-(E)-ylidene]-tert-butyl-amine

{[2‐(methylsulfanyl)ethoxy]methyl}benzene

Refernces

• 1、 -. "CONDENSED PYRROLES AS NOVEL BROMODOMAIN INHIBITORS". Paragraph 0098-00100; 00103-00104. . Retrieved 2020/07/14.
• 2、 -. "Preparation method of high purity 2-benzyloxy bromoethane". . . Retrieved 2019/07/11.