Alizarin Fluorine Blue

Base Information

• Chemical Name: Alizarin Fluorine Blue
• CAS No.: 3952-78-1
• Deprecated CAS: 31034-02-3
• Molecular Formula: C19H15NO8
• Molecular Weight: 385.33
• Hs Code.: 29225090
• European Community (EC) Number: 223-544-2
• NSC Number: 293056
• UNII: TX8W05MTS6
• DSSTox Substance ID: DTXSID4063240
• Nikkaji Number: J8.279A
• Wikidata: Q27123958
• Metabolomics Workbench ID: 58540
• Mol file: 3952-78-1.mol

Synonyms:alizarin complexone;alizarin fluorine blue

Chemical Property of Alizarin Fluorine Blue

Chemical Property:

• Appearance/Colour: orange-brown crystals
• Melting Point: ~185 °C (dec.)
• Refractive Index: 1.5000 (estimate)
• Boiling Point: 687.1 °C at 760 mmHg
• PKA: 1.71±0.10(Predicted)
• Flash Point: 369.4 °C
• PSA: 152.44000
• Density: 1.641 g/cm³
• LogP: 0.84440
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble (0.2 g/L)
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 6
• Exact Mass: 385.07976644
• Heavy Atom Count: 28
• Complexity: 648

Purity/Quality:

98%,99%, ^*data from raw suppliers

Alizarin Complexone >70.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Dyes -> Anthraquinone Dyes
• Canonical SMILES: C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C(=C3)CN(CC(=O)O)CC(=O)O)O)O
• Description: Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions. It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae. It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC50 = 35 nM).
• Uses: Alizarin Complexone is used for the determination of fluorine and other anions. ATA is also a potent inhibitor of protein-nucleic acid interactions. Alizarin-3-methyliminodiacetic acid has been used:for live staining of mineralized bone matrixto double-label the bone for dynamic bone histomorphometry at the femoral mid-diaphysis in the ratas a label in histomorphometry of the tibial diaphysis to indicate new bone formation in the rat Alizarin is the main ingredient for the manufacture of the madder lake pigments known to painters as Rose madder and Alizarin crimson. A notable use of alizarin in modern times is as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color. Alizarin Red is used in a biochemical assay to determine, quantitatively by colorimetry, the presence of calcific deposition by cells of an osteogenic lineage.

Technology Process of Alizarin Fluorine Blue

There total 2 articles about Alizarin Fluorine Blue which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,2-dihydroxy-9,10-anthracenedione (72-48-0,84754-86-9) + iminodiacetic acid (142-73-4) → alizarin complexone (3952-78-1)

Guidance literature:

With sodium hydroxide;

Reference yield:

→ alizarin complexone (3952-78-1)

Guidance literature:

Alzarin, Formaldehyd, Iminodiessigsaeure;

DOI:10.1039/jr9600004477

Reference yield:

C6H4CH2NHB(OH)2CH2C6(C2H5)3(CH2NHC3H6N2)2(2+) + alizarin complexone (3952-78-1) → C6H4CH2NHB(OH)2CH2C6(C2H5)3(CH2NHC3H6N2)2(2+)*C6H4(CO)2C6H(OH)2CH2NH(CH2COO)CH2COOH

Guidance literature:

With HEPES buffer; In methanol; water; in buffer soln. (HEPES in 25% water in MeOH by volume, pH 7.4); monitoring by UV/VIS;

DOI:10.1021/ja040006e

upstream raw materials:

formaldehyd

1,2-dihydroxy-9,10-anthracenedione

iminodiacetic acid