7A-Methyl-19-nortestosterone

Base Information

• Chemical Name: 7A-Methyl-19-nortestosterone
• CAS No.: 3764-87-2
• Molecular Formula: C19H28O2
• Molecular Weight: 288.43
• NSC Number: 142229
• Mol file: 3764-87-2.mol

Synonyms:7A-METHYL-19-NORTESTOSTERONE;NSC-142229;Estr-4-en-3-one, 17.beta.-hydroxy-7.alpha.-methyl-;SCHEMBL24102494;(7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one;19-Nor-7.alpha.-methyltestosterone;7.alpha.-Methyl-19-nortestosterone;NSC142229;(7R)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one;PD074455;7-ALPHA-METHYL-19-NORTESTOSTERONE;Trestolone;19-Nor-7a-methyltestosterone;(7R)-17-Hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one

Chemical Property of 7A-Methyl-19-nortestosterone

Chemical Property:

• Vapor Pressure: 1.44E-09mmHg at 25°C
• Melting Point: 145-146 °C
• Refractive Index: 1.557
• Boiling Point: 439.4 °C at 760 mmHg
• PKA: 15.06±0.60(Predicted)
• Flash Point: 187.3°C
• PSA: 37.30000
• Density: 1.119 g/cm³
• LogP: 3.73510
• Water Solubility.: 92mg/L(37 oC)
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 288.208930132
• Heavy Atom Count: 21
• Complexity: 494

Purity/Quality:

99% ^*data from raw suppliers

TRESTOLONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2=CC(=O)CCC2C3C1C4CCC(C4(CC3)C)O
• Uses: Trestolone is a synthetic androgen used as a potential hormonal male contraceptive method that induces a state of termporary infertility.

Technology Process of 7A-Methyl-19-nortestosterone

There total 10 articles about 7A-Methyl-19-nortestosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

17β-[(tert-butyldimethylsilyl)oxy]-7α-methylestr-4-en-3-one → 7α-methyl-19-nortestosterone (3764-87-2)

Guidance literature:

With water; sulfuric acid; In acetone; at 20 ℃; for 48h;

Reference yield: 60.5%

C21H30O3 → 7beta-Methyl-19-nortestosterone + 7α-methyl-19-nortestosterone (3764-87-2)

Guidance literature:

With water; potassium hydroxide; In methanol; toluene; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1021/op040010a

Reference yield:

7alpha-Methyl-19-nortestosterone acetate (6157-87-5) → 7α-methyl-19-nortestosterone (3764-87-2)

Guidance literature:

7alpha-Methyl-19-nortestosterone acetate; With methanol; potassium hydroxide; for 3 - 4h;

With citric acid; pH=6;

upstream raw materials:

7alpha-Methyl-19-nortestosterone acetate

19-nortestosterone

3,17β-diacetoxyoestra-3,5-diene

Downstream raw materials:

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

7α-methylnorethynodrel ethylene ketal

Refernces

• 1、 Martynow, Jacek,Krupa, Malgorzata,Les, Andrzej,Kutner, Andrzej,Szelejewski, Wieslaw. "Optimization of copper(I)-catalyzed 1,6-conjugate addition of a methyl group to 17β-acetoxy-4,6-estradien-3-one". . p. 846 - 851. Retrieved 2013/09/03.
• 2、 -. "Method for the control of fertility". . . Retrieved 2008/06/13.