2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid

Base Information

• Chemical Name: 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid
• CAS No.: 1447497-21-3
• Molecular Formula: C₁₄H₁₉NO₈
• Molecular Weight: 329.307
• Mol file: 1447497-21-3.mol

Synonyms:2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid

Chemical Property of 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid

There total 3 articles about 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoate (1447497-19-9) → 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid (1447497-21-3) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6)

Guidance literature:

With methanol; water; sodium hydroxide; for 2h; Reflux;

DOI:10.1021/ma4010023

Reference yield:

2-hydroxy-4-nitrobenzoic acid (619-19-2) → 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid (1447497-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: potassium carbonate / acetone / Inert atmosphere; Reflux

3: sodium hydroxide; water; methanol / 2 h / Reflux

With methanol; sulfuric acid; water; potassium carbonate; sodium hydroxide; In acetone;

DOI:10.1021/ma4010023

Reference yield:

2-hydroxy-4-nitro-benzoic acid methyl ester (13684-28-1) → 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoic acid (1447497-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Inert atmosphere; Reflux

2: sodium hydroxide; water; methanol / 2 h / Reflux

With methanol; water; potassium carbonate; sodium hydroxide; In acetone;

DOI:10.1021/ma4010023

upstream raw materials:

methyl 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoate

2-hydroxy-4-nitrobenzoic acid

2-hydroxy-4-nitro-benzoic acid methyl ester

Downstream raw materials:

phenyl 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4-nitrobenzoate

phenyl 4-amino-2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzoate

phenyl 4-((4-methoxybenzyl)amino)-2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzoate

Refernces