2-Acetamidothiazole

Base Information

• Chemical Name: 2-Acetamidothiazole
• CAS No.: 2719-23-5
• Molecular Formula: C5H6 N2 O S
• Molecular Weight: 142.181
• Hs Code.: 29341000
• European Community (EC) Number: 220-321-1
• NSC Number: 44844,18750
• UNII: O94697VKTV
• DSSTox Substance ID: DTXSID3062607
• Nikkaji Number: J37.302H
• Wikidata: Q27285499
• Mol file: 2719-23-5.mol

Synonyms:2-Acetamidothiazole;2719-23-5;2-Acetylaminothiazole;N-(thiazol-2-yl)acetamide;N-(1,3-Thiazol-2-yl)acetamide;Acetamide, N-2-thiazolyl-;N-2-Thiazolylacetamide;2-Acetamido-1,3-thiazole;2-Acetaminothiazole;Thiazole, 2-acetamido-;154446-32-9;N-Thiazol-2-ylacetamide;ACETAMIDE, N-(2-THIAZOLYL)-;EINECS 220-321-1;MFCD00016892;NSC 18750;NSC 44844;UNII-O94697VKTV;AI3-32922;O94697VKTV;NSC-18750;NSC-44844;Acetamide, N-2(3H)-thiazolylidene-;ACETAMIDE,N-2(3H)-THIAZOLYLIDENE-;acetylamino thiazole;2-acetylamino thiazole;ACETAMIDOTHIAZOLE;N-2-thiazolyl acetamide;Acetamide,N-2-thiazolyl-;N-(2-Thiazolyl)acetamide;2-Acetamidothiazole, 98%;N-(2-thiazolyl)-acetamide;SCHEMBL115951;DTXSID3062607;WXPLRSVMGRAIGW-UHFFFAOYSA-;AMY24875;NSC18750;NSC44844;AC7947;GEO-00020;N-(1,3-Thiazol-2-yl)acetamide #;STK054583;AKOS000279444;AKOS006223937;FS-4269;SY049337;BB 0301270;CS-0095600;FT-0610969;A877005;AB-601/30915014;J-640188;J-800189;W-200268;Q27285499;Z28173610;F0808-0926;WPY

Chemical Property of 2-Acetamidothiazole

Chemical Property:

• Appearance/Colour: LIGHT BROWN TO BEIGE CRYSTALLINE POWDER
• Melting Point: 202-206 °C (dec.)(lit.)
• Refractive Index: 1.6430 (estimate)
• Boiling Point: °Cat760mmHg
• PKA: 9.70±0.50(Predicted)
• Flash Point: °C
• PSA: 70.23000
• Density: 1.351g/cm³
• LogP: 1.17450
• Storage Temp.: Keep Cold
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 142.02008399
• Heavy Atom Count: 9
• Complexity: 118

Purity/Quality:

98% ^*data from raw suppliers

2-Acetamidothiazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=NC=CS1

Technology Process of 2-Acetamidothiazole

There total 15 articles about 2-Acetamidothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-acetamido-5-bromothiazole (7336-54-1) → 2-acetamidothiazole (2719-23-5)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane;

DOI:10.1016/0040-4039(96)00734-4

Reference yield: 86.0%

2-thiazolylamine (96-50-4) + acetic acid (64-19-7,77671-22-8) → 2-acetamidothiazole (2719-23-5)

Guidance literature:

With sulfuric acid; at 40 - 70 ℃; for 0.166667h;

DOI:10.1007/BF00764697

Reference yield: 76.0%

2-thiazolylamine (96-50-4) + acetic anhydride (108-24-7) → 2-acetamidothiazole (2719-23-5)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1039/c3ob41971a

upstream raw materials:

2-thiazolylamine

acetic anhydride

1,2-dibromoethyl acetate

thiourea

Downstream raw materials:

C₅H₅ClN₂O₃S₂

N-(5-(4-fluorophenyl)thiazol-2-yl)acetamide

2-acetamino-5-thiocyanatothiazole

2-thiazolylamine

Refernces

• 1、 Xiong, Biquan,Wang, Gang,Xiong, Tao,Wan, Liming,Zhou, Congshan,Liu, Yu,Zhang, Panliang,Yang, Changan,Tang, Kewen. "Direct synthesis of N-arylamides via the coupling of aryl diazonium tetrafluoroborates and nitriles under transition-metal-free conditions". supporting information. p. 3139 - 3142. Retrieved 2018/07/13.
• 2、 -. "NOVEL COMPOUNDS". Page/Page column 100. . Retrieved 2016/04/20.