2-Iodopyridine

Base Information

• Chemical Name: 2-Iodopyridine
• CAS No.: 5029-67-4
• Molecular Formula: C5H4IN
• Molecular Weight: 204.998
• Hs Code.: 29333990
• NSC Number: 5075
• DSSTox Substance ID: DTXSID60903821
• Nikkaji Number: J151.448B
• ChEMBL ID: CHEMBL3274303
• Mol file: 5029-67-4.mol

Synonyms:2-iodopyridine

Chemical Property of 2-Iodopyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Melting Point: 118 - 120oC
• Refractive Index: n20/D 1.6320(lit.)
• Boiling Point: 215.4 °C at 760 mmHg
• PKA: pK1:1.82(＋1) (25°C)
• Flash Point: 84.1 °C
• PSA: 12.89000
• Density: 1.957 g/cm³
• LogP: 1.68620
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 204.93885
• Heavy Atom Count: 7
• Complexity: 56

Purity/Quality:

98%+ ^*data from raw suppliers

2-Iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)I
• Uses: 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors. 2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.

Technology Process of 2-Iodopyridine

There total 6 articles about 2-Iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

→ 2-iodopyridine (5029-67-4) + 4-Iodo-2-methoxy-3-methyl-6-trimethylsilylpyridine (305816-04-0)

Guidance literature:

Reference yield:

pyridine (110-86-1) + cyclohexane (110-82-7,25012-93-5) → 2-iodopyridine (5029-67-4) + 2-pyridylcyclohexane (15787-49-2) + 4-cyclohexylpyridine (13669-35-7) + cyclohexyl chloride (542-18-7) + Cyclohexyl iodide (626-62-0)

Guidance literature:

With 2-Picolinic acid; dihydrogen peroxide; lithium chloride; lithium bromide; iron(II) chloride; at 0 ℃; Product distribution; Kinetics;

DOI:10.1016/S0040-4020(97)00447-X

Reference yield:

pyridine (110-86-1) + cyclohexane (110-82-7,25012-93-5) → 2-iodopyridine (5029-67-4) + 1-bromocyclohexane (108-85-0) + cyclohexyl chloride (542-18-7) + Cyclohexyl iodide (626-62-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + cyclohexanol (108-93-0)

Guidance literature:

With 2-Picolinic acid; dihydrogen peroxide; iodine; iron(III) chloride; lithium chloride; lithium bromide; at 0 ℃; Product distribution; Kinetics;

DOI:10.1016/S0040-4020(97)00447-X

upstream raw materials:

N-fluoropyridinium triflate

pyridine

cyclohexane

2,3-dimethyl-2,3-diaminobutane

Downstream raw materials:

tri-(2-pyridyl)amine

2-pyridyl benzoate

sulphapyridine

[2,2]bipyridinyl

Refernces

• 1、 -. "Compounds and their use". . . Retrieved 2008/06/13.
• 2、 Barton, Derek H.R.,Costas Salgueiro, Miquel,MacKinnon, John. "The functionalization of saturated hydrocarbons. Part 39. Further evidence for the role of the iron-carbon bond in Gif chemistry". . p. 7417 - 7428. Retrieved 2007/10/03.