Perfluorodecalin

Base Information

• Chemical Name: Perfluorodecalin
• CAS No.: 306-94-5
• Deprecated CAS: 127964-38-9,70323-33-0,77115-10-7,159813-90-8,1201928-37-1,1201928-37-1,159813-90-8,70323-33-0
• Molecular Formula: C10F18
• Molecular Weight: 462.081
• Hs Code.: 29038900
• European Community (EC) Number: 206-192-4,671-179-6
• NSC Number: 97066
• UNII: 54A06VV62N
• DSSTox Substance ID: DTXSID0046511,DTXSID201015480,DTXSID801021518
• Nikkaji Number: J374.602J,J60.089J,J791.509H
• Wikipedia: Perfluorodecalin
• Wikidata: Q413677
• NCI Thesaurus Code: C90817
• RXCUI: 2462501
• ChEMBL ID: CHEMBL1371129
• Mol file: 306-94-5.mol

Synonyms:decalin perfluoride;DKLine;fluosol-DC;perfluorodecalin;perfluorodecalin, (cis)-isomer;perfluorodecalin, (trans)-isomer

Chemical Property of Perfluorodecalin

Chemical Property:

• Appearance/Colour: clear colourless liquid
• Vapor Pressure: 6.8mmHg at 25°C
• Melting Point: -10 °C(lit.)
• Refractive Index: n20/D 1.3145(lit.)
• Boiling Point: 143.1 °C at 760 mmHg
• Flash Point: 46.4 °C
• PSA: 0.00000
• Density: 1.83 g/cm³
• LogP: 5.51260
• Storage Temp.: Store below +30°C.
• Water Solubility.: Insoluble
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 0
• Exact Mass: 461.9712569
• Heavy Atom Count: 28
• Complexity: 587

Purity/Quality:

99.9% ^*data from raw suppliers

Perfluorodecalin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, F
• Hazard Codes: Xi,F
• Statements: 10
• Safety Statements: 23-24/25-41-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C12(C(C(C(C(C1(F)F)(F)F)(F)F)(F)F)(C(C(C(C2(F)F)(F)F)(F)F)(F)F)F)F
• Description: Perfluorodecalin (PFD) is a chemically and biologicallyinert biomaterial and, as many perfluorocarbons, is alsohydrophobic, radiopaque and has a high solute capacity forgases such as oxygen.Perfluorodecalin is a fluorocarbon and derivative of decalin, and used in cosmetics and beauty products as to dissolve and deliver oxygen to the skin in formulas (Wikipedia). It is also used as a skin conditioning agent, detangler, and solvent in some formulas. Perfluorodecalin's ability to dissolve oxygen is thought to revitalize skin and reduce wrinkles, increasing the partial pressure of oxygen (pO2), according to research.Some studies have shown that formulas that include Perflurodecalin improve the skin's barrier function resulting in increased moisturizing efficacy. However, there are no studies to prove that added oxygen can actually repair wrinkled skin or prevent lines from forming. Conversely, too much oxygen can enhance the number of unstable oxygen molecules which cause free radical damage.
• Uses: Perfluorodecalin is a fluorous solvent generally used as a primary component of the fluorous biphasic system (FBS) or the fluorous multiphasic system (FMS) in synthetic chemistry. It is also used as an additive to increase oxygen solubility in fermentation media. Perfluorodecalin is used as a building block reagent as well maintains ability to dissolve gases such as oxygen and increase oxygen to a location allowing for medicinal uses such as preserving tissue after pancreas transplants.

Technology Process of Perfluorodecalin

There total 6 articles about Perfluorodecalin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

naphthalene (91-20-3,71998-51-1,72931-45-4) → octadecafluorodecahydronaphthalene (cis+trans) (306-94-5)

Guidance literature:

With silver(II) fluoride; at 225 - 330 ℃;

DOI:10.1021/ie50447a630

Reference yield:

decalin (91-17-8) → octadecafluorodecahydronaphthalene (cis+trans) (306-94-5)

Guidance literature:

With silver(II) fluoride; at 225 - 330 ℃;

DOI:10.1021/ie50447a630

Reference yield:

1-Chloronaphthalene (90-13-1) → octadecafluorodecahydronaphthalene (cis+trans) (306-94-5)

Guidance literature:

With silver(II) fluoride; at 225 - 330 ℃;

DOI:10.1021/ie50447a630

upstream raw materials:

naphthalene

tetralin

decalin

1-Chloronaphthalene

Downstream raw materials:

octakis(phenylthio)naphthalene

octafluoronaphthalene

1,3,4,5,6,7,8-heptafluoronaphthalene

perfluorotetralin

Refernces

• 1、 Oliver et al.. "". . p. 19,23, 31. Retrieved 1975.
• 2、 Zakharov, V. Yu.,Denisov, A. K.,Novikova, M. D.. "DIRECT GAS-PHASE CATALYTIC FLUORINATION OF PARTIALLY FLUORINATED ORGANIC COMPOUNDS". . p. 1942 - 1945. Retrieved 2007/10/03.