N-Acetyl methyl ester amb

Base Information

• Chemical Name: N-Acetyl methyl ester amb
• CAS No.: 62008-36-0
• Molecular Formula: C50H77NO18
• Molecular Weight: 980.157
• Mol file: 62008-36-0.mol

Synonyms:N-acetyl methyl ester AmB;N-acetylamphotericin B methyl ester

Chemical Property of N-Acetyl methyl ester amb

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1162.4°C at 760 mmHg
• Flash Point: 656.8°C
• PSA: 315.18000
• Density: 1.31g/cm³
• LogP: 1.81780
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 11
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 5
• Exact Mass: 979.51406461
• Heavy Atom Count: 69
• Complexity: 1800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)OC)OC3C(C(C(C(O3)C)O)NC(=O)C)O
• Isomeric SMILES: CC1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)OC)OC3C(C(C(C(O3)C)O)NC(=O)C)O

Technology Process of N-Acetyl methyl ester amb

There total 4 articles about N-Acetyl methyl ester amb which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + C47H73NO17C2H2O (902457-23-2) → N-acetylamphotericin B methyl ester (62008-36-0)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1039/c39860000413

Reference yield:

AmBisome (1397-89-3) → N-acetylamphotericin B methyl ester (62008-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfoxide; methanol / 0 °C

2: diethyl ether / 0 °C

In methanol; diethyl ether; dimethyl sulfoxide;

DOI:10.1039/c39860000413

Reference yield:

→ N-Acetyl-amphotericin B-methylester (62008-36-0,113474-08-1)

Guidance literature:

N-Acetyl-amphotericin B, CH2N2;

upstream raw materials:

diazomethane

C₄₇H₇₃NO₁₇C₂H₂O

AmBisome

Refernces