C₄₉H₅₆N₄O₁₃

Base Information

• Chemical Name: C₄₉H₅₆N₄O₁₃
• CAS No.: 1372688-63-5
• Molecular Formula: C₄₉H₅₆N₄O₁₃
• Molecular Weight: 909.003
• Mol file: 1372688-63-5.mol

Synonyms:C₄₉H₅₆N₄O₁₃

Chemical Property of C₄₉H₅₆N₄O₁₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₅₆N₄O₁₃

There total 5 articles about C₄₉H₅₆N₄O₁₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C13H22N2O7 (1095223-93-0) + dibenzyl L-aspartate toluene-4-sulphonate (2886-33-1) → C49H56N4O13 (1372688-63-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2012.02.040

Reference yield:

C13H22N2O7 (1095223-93-0) + dibenzyl L-aspartate (2791-79-9) → C49H56N4O13 (1372688-63-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.chemphyslip.2019.104832

Reference yield:

N,N-bis(2-ethoxycarbonylethyl)benzylamine (6938-07-4) → C49H56N4O13 (1372688-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; ammonium formate / methanol / 20 °C

1.2: -15 - 20 °C

1.3: 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With palladium on activated charcoal; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

DOI:10.1016/j.chemphyslip.2019.104832

upstream raw materials:

C₁₃H₂₂N₂O₇

dibenzyl L-aspartate toluene-4-sulphonate

BOC-glycine

dibenzyl L-aspartate

Downstream raw materials:

C₄₄H₄₈N₄O₁₁

Refernces

• 1、 Chen, Changqing,Xie, Changwei,Zhao, Yi,Zhao, Ze. "Design, synthesis and evaluation of liposomes modified with dendritic aspartic acid for bone-specific targeting". . . Retrieved 2019/11/13.