Technology Process of (5Z,13E,15S)-15-[[(tert-Butyl)dimethylsilyl]oxy]-9-oxo-5,10,13-prostatrien-1-oic acid methyl ester
There total 2 articles about (5Z,13E,15S)-15-[[(tert-Butyl)dimethylsilyl]oxy]-9-oxo-5,10,13-prostatrien-1-oic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diethyl ether / 0.5 h / 0 - 5 °C
2: imidazole / dimethylformamide / 2 h / Ambient temperature
With
1H-imidazole;
In
diethyl ether; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / 30percent hydrogen peroxide, 3 M aq. lithium hydroxide / methanol / 5 h / -30 - -25 °C
2: aq. sodium hydrogen carbonate, aluminium amalgam / tetrahydrofuran; methanol / 1.) 10 deg C, 2 h, 2.) room temperature, 4 h
3: 80 percent / K-Selectride / tetrahydrofuran / 5 h / -50 - -45 °C
4: hydrofluoric acid / acetonitrile / 1 h / -5 °C
5: base hydrolysis
With
lithium hydroxide; aluminium amalgam; hydrogen fluoride; dihydrogen peroxide; sodium hydrogencarbonate; potassium tri-sec-butyl-borohydride;
In
tetrahydrofuran; methanol; acetonitrile;