(R)-(+)-1,2-Diaminopropane dihydrochloride

Base Information

• Chemical Name: (R)-(+)-1,2-Diaminopropane dihydrochloride
• CAS No.: 19777-67-4
• Molecular Formula: C₃H₁₂N₂*2Cl
• Molecular Weight: 147.048
• Hs Code.: 2921290000
• European Community (EC) Number: 628-008-5
• DSSTox Substance ID: DTXSID00480929
• Mol file: 19777-67-4.mol

Synonyms:19777-67-4;(R)-(+)-1,2-Diaminopropane dihydrochloride;(R)-1,2-Diaminopropane Dihydrochloride;(2R)-propane-1,2-diamine dihydrochloride;(R)-(+)-Diaminopropane Hydrochloride;MFCD00239481;(R)-propane-1,2-diamine dihydrochloride;(2R)-propane-1,2-diamine;dihydrochloride;(R)-Propylenediamine Dihydrochloride;1,2-Propanediamine, hydrochloride (1:2), (2R)-;(R)-(+)-1,2-Diaminopropane DiHCl;(R)-1,2-Diaminopropane 2HCl;1,2-Propanediamine, dihydrochloride, (2R)-;SCHEMBL202651;(R)-(+)-Diaminopropane 2HCl;AMY3648;DTXSID00480929;AEIAMRMQKCPGJR-HWYNEVGZSA-N;AKOS015845557;AKOS016015887;(R)-1,2-Propanediamine Dihydrochloride;AS-15788;R-(+)-1,2-Diaminopropane dihydrochloride;(R)-(-)-1,2-diaminopropane dihydrochloride;D2827;(R)-1,2-Diaminopropane dihydrochloride, 99%;P20461;EN300-6492099;(R)-(+)-1,2-Diaminopropane dihydrochloride, 99%;(R)-(+)-1,2-DIAMINOPROPANEDIHYDROCHLORIDE;J-200024;(2R)-Propane-1,2-diamine--hydrogen chloride (1/2);Z3234812272

Chemical Property of (R)-(+)-1,2-Diaminopropane dihydrochloride

Chemical Property:

• Appearance/Colour: WHITE TO OFF-WHITE POWDER OR CRYSTALS
• Vapor Pressure: 2.39mmHg at 25°C
• Melting Point: 241-244 °C(lit.)
• Boiling Point: 215.8 °C at 760 mmHg
• Flash Point: 84.3 °C
• PSA: 52.04000
• Density: 0.863g/cm3
• LogP: 2.29690
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 146.0377538
• Heavy Atom Count: 7
• Complexity: 20.9

Purity/Quality:

98% ^*data from raw suppliers

(R)-1,2-Diaminopropane Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN)N.Cl.Cl
• Isomeric SMILES: C[C@H](CN)N.Cl.Cl

Technology Process of (R)-(+)-1,2-Diaminopropane dihydrochloride

There total 15 articles about (R)-(+)-1,2-Diaminopropane dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-methyl-imidazolidin-2-one (6531-31-3) → (racemi)-1,2-diaminopropane dihydrochloride (19777-66-3,19777-67-4,20267-34-9,41889-20-7,62036-75-3)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 0.0333333h; microwave irradiation;

DOI:10.1080/00397910701464951

Reference yield: 97.0%

1-azido-2-aminopropane → (racemi)-1,2-diaminopropane dihydrochloride (19777-66-3,19777-67-4,20267-34-9,41889-20-7,62036-75-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 3102.9 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)91013-0

Reference yield: 95.0%

[Ni(1,2-diaminopropane)2Cl2]*3H2O + salicylaldehyde (90-02-8) → [Ni(OC6H4CHNCH2CH(CH3)NCHC6H4O)]*0.5H2O + (racemi)-1,2-diaminopropane dihydrochloride (19777-66-3,19777-67-4,20267-34-9,41889-20-7,62036-75-3)

Guidance literature:

In ethanol; soln. of org. compd. added to soln. of complex, refluxed for 3 h; allowed to cool slowly to room temp., filtered, washed with EtOH and Et2O, air-dried, elem. anal.;

DOI:10.1081/SIM-100105251

upstream raw materials:

4-methyl-imidazolidin-2-one

salicylaldehyde

1,2-diaminopropan

(S)-tert-butyl 1-aminopropan-2-ylcarbamate

Downstream raw materials:

(2S)-[N,N'-bis(2'-hydroxy-3',5'-di-tert-butylbenzylidene)]-1,2-diaminopropane

(2S)-[N,N'-bis(2'-hydroxybenzylidene)]-1,2-diaminopropane

((S)-2-aminopropyl)carbamic acid tert-butyl ester

(2S)-N¹-[4-(3,5-Dimethyl-1,2-oxazol-4-yl)-2-nitrophenyl]propane-1,2-diamine

Refernces

• 1、 -. "Preparation method of dexrazoxane". Paragraph 0023-0024. . Retrieved 2021/11/14.
• 2、 Petersen, Johannes F.,Tortzen, Christian G.,Pittelkow, Michael,Christensen, J?rn B.. "Synthesis and properties of chiral internally branched PAMAM-dendrimers". . p. 1109 - 1116. Retrieved 2015/02/19.