2-(2-Chlorophenyl)-4,5-diphenyl-1H-imidazole

Base Information

• Chemical Name: 2-(2-Chlorophenyl)-4,5-diphenyl-1H-imidazole
• CAS No.: 1707-67-1
• Molecular Formula: C21H15ClN2
• Molecular Weight: 330.816
• Hs Code.: 2933290090
• European Community (EC) Number: 216-951-1
• DSSTox Substance ID: DTXSID8061894
• Nikkaji Number: J106.063E
• Wikidata: Q72456781
• ChEMBL ID: CHEMBL427244
• Mol file: 1707-67-1.mol

Synonyms:1707-67-1;2-(2-CHLOROPHENYL)-4,5-DIPHENYL-1H-IMIDAZOLE;2-(2-Chlorophenyl)-4,5-diphenylimidazole;C21H15ClN2;1H-Imidazole, 2-(2-chlorophenyl)-4,5-diphenyl-;2-(2-CHLORO-PHENYL)-4,5-DIPHENYL-1H-IMIDAZOLE;2-(o-Chlorophenyl)-4,5-diphenylimidazole;EINECS 216-951-1;SR-03000000729-1;Oprea1_512587;cid_74356;SCHEMBL306063;CHEMBL427244;DTXSID8061894;BDBM67507;C21-H15-Cl-N2;MFCD00030328;AKOS015900326;AC-8723;AC-16732;AS-30428;C2240;CS-0171300;FT-0633784;W-107883

Chemical Property of 2-(2-Chlorophenyl)-4,5-diphenyl-1H-imidazole

Chemical Property:

• Appearance/Colour: Yellowish powder
• Vapor Pressure: 5.67E-11mmHg at 25°C
• Melting Point: 197 °C
• Refractive Index: 1.645
• Boiling Point: 534.8 °C at 760 mmHg
• PKA: 11.09±0.12(Predicted)
• Flash Point: 307.8 °C
• PSA: 28.68000
• Density: 1.23 g/cm³
• LogP: 6.06410
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 330.0923762
• Heavy Atom Count: 24
• Complexity: 389

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Chlorophenyl)-4,5-diphenyl-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C,Xi
• Hazard Codes: F,C,Xi

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=CC=C3Cl)C4=CC=CC=C4

Technology Process of 2-(2-Chlorophenyl)-4,5-diphenyl-1H-imidazole

There total 11 articles about 2-(2-Chlorophenyl)-4,5-diphenyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-benzaldehyde (89-98-5) + benzil (134-81-6) → 2-(2-chlorophenyl)-4,5-diphenyl-1H-imidazole (1707-67-1,6143-80-2)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In neat (no solvent); at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1039/d1ra05802a

Reference yield: 96.0%

2-chloro-benzaldehyde (89-98-5) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → 2-(2-chlorophenyl)-4,5-diphenyl-1H-imidazole (1707-67-1,6143-80-2)

Guidance literature:

With ammonium acetate; 1-butylimidazolium tetrafluoroborate; at 100 ℃; for 1.16667h;

DOI:10.1016/j.tet.2005.01.116

Reference yield: 93.0%

ammonium acetate (631-61-8,92206-38-7) + 2-chloro-benzaldehyde (89-98-5) + benzil (134-81-6) → 2-(2-chlorophenyl)-4,5-diphenyl-1H-imidazole (1707-67-1,6143-80-2)

Guidance literature:

With molybdenum oxide supported on silica; In acetonitrile; at 80 ℃; for 3h;

DOI:10.1080/00397911003644415

upstream raw materials:

2-chloro-benzaldehyde

benzil

2-hydroxy-2-phenylacetophenone

ammonium acetate

Downstream raw materials:

C₄₂H₂₆Cl₄N₄

C₄₂H₂₆Cl₄N₄

C₄₂H₂₄Cl₆N₄

2,2'-di(ortho-chlorophenyl)-4,4',5,5'-tetraphenyl-2'H-1,2'-biimidazole

Refernces

• 1、 Gharibi, Saideh,Maleki, Ali,Taheri-Ledari, Reza,Valadi, Kobra. "Pumice-modified cellulose fiber: An environmentally benign solid state hybrid catalytic system for the synthesis of 2,4,5-triarylimidazole derivatives". . . Retrieved 2020.
• 2、 Hamidi, Zeinab,Karimi Zarchi, Mohammad Ali. "Synthesis of polymer-supported Fe3O4 nanoparticles and their application as a novel route for the synthesis of imidazole derivatives". . p. 6995 - 7011. Retrieved 2018.
• 3、 Heravi, Majid M.,Zakeri, Masoumeh,Haghi, Hoda. "MCM-41 mesoporous silica: Efficient and reusable catalyst for the synthesis of 2,4,5-trisubstituted imidazoles under solvent-free conditions". . p. 1310 - 1314. Retrieved 2011.
• 4、 Zang, Hongjun,Su, Qiuhong,Mo, Yingming,Cheng, Bo-Wen,Jun, Song. "Ionic liquid [EMIM]OAc under ultrasonic irradiation towards the first synthesis of trisubstituted imidazoles". . p. 749 - 751. Retrieved 2010.
• 5、 Bhosale, Sidhanath V.,Kalyankar, Mohan B.,Nalage, Santosh V.,Bhosale, Dattatry S.,Pandhare, Swati L.,Kotbagi, Trupti V.,Umbarkar, Shubhangi B.,Dongare, Mohan K.. "One-pot synthesis of 2,4,5-trisubstituted imidazoles using MoO 3/SiO2, an efficient and recyclable catalyst". . p. 762 - 769. Retrieved 2011.
• 6、 Amoozadeh, Ali,Kolvari, Eskandar,Sakhdari, Mahnaz. "Magnetic nanoparticle-supported sulfonic acid as a green catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles under solvent-free conditions". . p. 71 - 78. Retrieved 2021/10/30.
• 7、 Indalkar, Krishna,Malge, Sanjay S.,Mali, Anil S.,Chaturbhuj, Ganesh U.. "Expeditious and Highly Efficient One-Pot Synthesis of Functionalized Imidazoles Catalyzed by Sulfated Polyborate". . p. 387 - 396. Retrieved 2021/07/26.