C₃₇H₄₄N₄O₅

Base Information

• Chemical Name: C₃₇H₄₄N₄O₅
• CAS No.: 1613625-08-3
• Molecular Formula: C₃₇H₄₄N₄O₅
• Molecular Weight: 624.78
• Mol file: 1613625-08-3.mol

Synonyms:C₃₇H₄₄N₄O₅

Chemical Property of C₃₇H₄₄N₄O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₄N₄O₅

There total 19 articles about C₃₇H₄₄N₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C42H52N4O7 (1613625-07-2) → C37H44N4O5 (1613625-08-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid (3562-99-0) → C37H44N4O5 (1613625-08-3)

Guidance literature:

Multi-step reaction with 19 steps

1.1: hydrogenchloride; zinc / toluene / 2 h / Reflux

2.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C

2.2: 3.5 h / 0 - 20 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 °C

3.3: 16 h / -78 - 27 °C

4.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C

5.1: hydrogen; palladium 10% on activated carbon / water / 3 h / 20 °C / 760.05 Torr

6.1: acetic acid; hydrogen bromide / 4 h / Reflux

7.1: acetyl chloride / 4 h / 0 °C / Reflux

8.1: sodium hydrogencarbonate / methanol; water / 3 h / 0 - 20 °C

9.1: pyridine / 2.5 h / 0 - 20 °C

10.1: tri-tert-butyl phosphine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile; hexane / 5 h / Inert atmosphere; Reflux

11.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

12.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C

13.1: ammonia / methanol / 18 h / 0 - 20 °C

14.1: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 20 °C / 760.05 Torr

15.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

16.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 6 h / 20 °C

17.1: acetic acid; sodium cyanoborohydride / methanol / 19 h / 20 °C

18.1: sodium hydrogencarbonate / methanol; water / 0.17 h / 0 °C

18.2: 3 h / 0 - 20 °C

19.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tri-tert-butyl phosphine; palladium 10% on activated carbon; ammonia; water; hydrogen bromide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; triethylamine; acetyl chloride; sodium hydroxide; lithium hydroxide; zinc; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

γ-(4-methoxy-1-naphthyl)butyric acid (10465-20-0) → C37H44N4O5 (1613625-08-3)

Guidance literature:

Multi-step reaction with 18 steps

1.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C

1.2: 3.5 h / 0 - 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 °C

2.3: 16 h / -78 - 27 °C

3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C

4.1: hydrogen; palladium 10% on activated carbon / water / 3 h / 20 °C / 760.05 Torr

5.1: acetic acid; hydrogen bromide / 4 h / Reflux

6.1: acetyl chloride / 4 h / 0 °C / Reflux

7.1: sodium hydrogencarbonate / methanol; water / 3 h / 0 - 20 °C

8.1: pyridine / 2.5 h / 0 - 20 °C

9.1: tri-tert-butyl phosphine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile; hexane / 5 h / Inert atmosphere; Reflux

10.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

11.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C

12.1: ammonia / methanol / 18 h / 0 - 20 °C

13.1: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 20 °C / 760.05 Torr

14.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

15.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 6 h / 20 °C

16.1: acetic acid; sodium cyanoborohydride / methanol / 19 h / 20 °C

17.1: sodium hydrogencarbonate / methanol; water / 0.17 h / 0 °C

17.2: 3 h / 0 - 20 °C

18.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tri-tert-butyl phosphine; palladium 10% on activated carbon; ammonia; water; hydrogen bromide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; triethylamine; acetyl chloride; sodium hydroxide; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; acetonitrile;

upstream raw materials:

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

γ-(4-methoxy-1-naphthyl)butyric acid

(S)-4-benzyl-3-(4-(4-methoxynaphthalen-1-yl)butanoyl)oxazolidin-2-one

(S)-3-((S)-2-azido-4-(4-methoxynaphthalen-1-yl)butanoyl)-4-benzyloxazolidin-2-one

Refernces

• 1、 -. "3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS". . . Retrieved 2014/07/08.