N-(2-Methoxy-5-methylphenyl)acetamide

Base Information

• Chemical Name: N-(2-Methoxy-5-methylphenyl)acetamide
• CAS No.: 6962-44-3
• Molecular Formula: C10 H13 N O2
• Molecular Weight: 179.219
• Hs Code.: 2924299090
• European Community (EC) Number: 230-157-2
• NSC Number: 109456,37057
• DSSTox Substance ID: DTXSID7064522
• Nikkaji Number: J58.397I
• Wikidata: Q72490569
• Mol file: 6962-44-3.mol

Synonyms:6962-44-3;N-(2-Methoxy-5-methylphenyl)acetamide;6-Methoxy-meta-acetoluidide;N-(2-METHOXY-5-METHYLPHENYL)-ACETAMIDE;Acetamide, N-(2-methoxy-5-methylphenyl)-;3-Acetylamino-4-methoxytoluene;NSC 37057;5'-Methyl-o-acetanisidide;EINECS 230-157-2;NSC 109456;4-chloro-2-methylbenzenediazonium zinc chloride(1:1:3);EC 230-157-2;SCHEMBL6579496;DTXSID7064522;2'-Methoxy-5'-methylacetanilide;NSC37057;NSC-37057;NSC109456;AKOS002958664;NSC-109456;N-(2-Methoxy-5-methyl-phenyl)-acetamide;N-(2-Methoxy-5-methylphenyl)acetamide #;FT-0693624;A836567;W-110186

Chemical Property of N-(2-Methoxy-5-methylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 0.000648mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 309.2 °C at 760 mmHg
• Flash Point: 140.8 °C
• PSA: 38.33000
• Density: 1.1g/cm³
• LogP: 2.03500
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 182

Purity/Quality:

99% ^*data from raw suppliers

N-(2-methoxy-5-methylphenyl)acetamide AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)OC)NC(=O)C
• Uses: N-(2-Methoxy-5-methylphenyl)-acetamide is a dye intermediate.

Technology Process of N-(2-Methoxy-5-methylphenyl)acetamide

There total 8 articles about N-(2-Methoxy-5-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methanol (67-56-1) + 3-Methylacetanilide (537-92-8) → N-(2-methoxy-5-methylphenyl)acetamide (6962-44-3)

Guidance literature:

With dipotassium peroxodisulfate; methanesulfonic acid; palladium diacetate; In 1,2-dimethoxyethane; at 25 ℃; for 24h;

DOI:10.1021/jo301964m

Reference yield:

methyl bromide (74-83-9) + 2-acetylamino-p-cresol (6375-17-3) → N-(2-methoxy-5-methylphenyl)acetamide (6962-44-3)

Guidance literature:

at 50 - 95 ℃; under 757.576 - 1500.15 Torr;

Reference yield:

dimethyl sulfate (77-78-1) + 2-acetylamino-p-cresol (6375-17-3) → N-(2-methoxy-5-methylphenyl)acetamide (6962-44-3)

Guidance literature:

at 100 ℃; under 760.051 Torr;

upstream raw materials:

acetic acid

Cresidine

acetyl chloride

methanol

Downstream raw materials:

N-(4-Acetylamino-5-methoxy-2-methyl-benzyl)-2-chloro-acetamide

N-(2-methoxy-5-methyl-4-(N-(phenylsulfonyl)phenylsufonamido)phenyl)acetamide

4-chloro-5-methoxy-2-methylaniline

1-chloro-2-methoxy-5-methyl-4-nitrobenzene

Refernces

• 1、 Jiang, Tao-Shan,Wang, Guan-Wu. "Palladium-catalyzed ortho-alkoxylation of anilides via C-H activation". . p. 9504 - 9509,6. Retrieved 2012/12/12.
• 2、 -. "Compounds and methods for doping liquid crystal hosts". . . Retrieved 2008/06/13.