Bromo-PEG6-alcohol

Base Information

• Chemical Name: Bromo-PEG6-alcohol
• CAS No.: 136399-05-8
• Molecular Formula: C₁₂H₂₅BrO₆
• Molecular Weight: 345.231
• Mol file: 136399-05-8.mol

Synonyms:17-bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol

Chemical Property of Bromo-PEG6-alcohol

Chemical Property:

• Boiling Point: 404.9±40.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• Density: 1.282±0.06 g/cm3(Predicted)
• Solubility.: Soluble in Water, DCM

Purity/Quality:

99.3% ^*data from raw suppliers

Bromo-PEG6-alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bromo-PEG6-alcohol is a PEG linker containing a bromide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Technology Process of Bromo-PEG6-alcohol

There total 5 articles about Bromo-PEG6-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

18-<4'-(benzo-15-crown-5)sulfonyl>-3,6,9,12,15,18-hexaoxa-1-octadecanol (136398-99-7) → 17-bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol (136399-05-8)

Guidance literature:

With lithium bromide; In acetone; for 5h; Heating;

Reference yield: 81.0%

pentaethylene glycol (2615-15-8) → 17-bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol (136399-05-8)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 30 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c7ta04599a

Reference yield: 76.2%

toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester (42749-28-0) → 17-bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol (136399-05-8)

Guidance literature:

With lithium bromide; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

upstream raw materials:

18-<4'-(benzo-15-crown-5)sulfonyl>-3,6,9,12,15,18-hexaoxa-1-octadecanol

17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl methanesulfonate

pentaethylene glycol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

pentaethylene glycol

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

Refernces

• 1、 Yang, Guang,Chanthad, Chalathorn,Oh, Hyukkeun,Ayhan, Ismail Alperen,Wang, Qing. "Organic-inorganic hybrid electrolytes from ionic liquid-functionalized octasilsesquioxane for lithium metal batteries". . p. 18012 - 18019. Retrieved 2017/09/08.
• 2、 -. "CONJUGATES COMPRISING PEPTIDE GROUPS AND METHODS RELATED THERETO". . . Retrieved 2017/08/08.