Zinc pyrithione

Base Information

• Chemical Name: Zinc pyrithione
• CAS No.: 13463-41-7
• Molecular Formula: 2(C5H4NOS)^.Zn
• Molecular Weight: 317.708
• Hs Code.: 2933.39
• UN Number: 2811
• Wikipedia: Zinc_pyrithione
• RXCUI: 39952
• Mol file: 13463-41-7.mol

Synonyms:(T-4)-bis(1-hydroxy-2(1H)- pyridinethionato-O,S)zinc;bis(1-hydroxy-2(1H)-pyridinethionato)zinc;bis(N-oxopyridine-2-thionato)zinc (II);Dan-Gard;de-squaman;pyrithione zinc;Sebulon;zinc pyridinethione;zinc pyrithione;zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4)-;zinc-2-pyridinethione-1-oxide;Zincon (zinc pyrithione);zincpolyanemine;ZNP;ZPT

Chemical Property of Zinc pyrithione

Chemical Property:

• Appearance/Colour: Fine beige granules
• Vapor Pressure: 0.00275mmHg at 25°C
• Melting Point: 262oC
• Boiling Point: 253.8 °C at 760 mmHg
• Flash Point: 107.3 °C
• PSA: 101.52000
• Density: 1.782 g/cm3 (25oC)
• LogP: 3.34050
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: almost transparency in Pyridine
• Water Solubility.: Insoluble (
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 315.931862
• Heavy Atom Count: 17
• Complexity: 183
• Transport DOT Label: Poison

Purity/Quality:

97%, ^*data from raw suppliers

1-Hydroxypyridine-2-thione zinc ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+,N,T
• Statements: 24/25-26-37/38-41-50/53-23-22
• Safety Statements: 26-28-36/37/39-45-61-60-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=[N+](C(=C1)[S-])[O-].C1=CC=[N+](C(=C1)[S-])[O-].[Zn+2]
• Recent EU Clinical Trials: Novel topical therapies for acne vulgaris: a randomised, controlled, double blind comparison of the antibacterial efficacy of 1% w/v formulations of tert-butylhydroquinone, zinc pyrithione and benzoyl peroxide in healthy volunteers
• Uses: Shampoo for dandruff,zinc pyrithione can inhibit Gram positive and negative bacteria and mold growth,Care hair Effectively , delay hair aging ,control white hair and hair loss generation. zinc pyrithion is also used as a cosmetic preservative, oil, paint biocide. Zinc pyrithione has a strong killing power on fungi and bacteria so that it can effectively kill dandruff fungus,playing a role in dandruff . Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks. Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing. zinc pyrithione is a preservative against bacteria, fungi, and yeast. It is unstable in light and in the presence of oxidizing agents. Zinc pyrithione is useful in gels, creams, heavy lotions, and talcum powder. Reactions may lead to photosensitive eczema and actinic reticuloid syndrome. Zinc pyrithione is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams.
• Description: Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
• Indications: Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.

Technology Process of Zinc pyrithione

There total 356 articles about Zinc pyrithione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

2-mercaptopyridine-1-oxide sodium salt (3811-73-2) + zinc(II) chloride (7646-85-7,24359-56-6) → zinc pyrithione (13463-41-7)

Guidance literature:

In water; at 70 ℃; for 1.16667h; Product distribution / selectivity;

Reference yield: 98.0%

triiron dodecarbonyl (17685-52-8) → iron pentacarbonyl (13463-40-6,37220-42-1)

Guidance literature:

With carbon monoxide; In n-heptane; Irradiation (UV/VIS); soln. of Fe3(CO)12 in n-heptane is irradiated for 30 min in slow streamof CO;

DOI:10.1016/S0277-5387(00)86658-9

Reference yield:

zinc(II) sulfate monohydrate (100685-55-0) + 2-mercaptopyridine-1-oxide sodium salt (3811-73-2) → zinc pyrithione (13463-41-7)

Guidance literature:

In water;

upstream raw materials:

2-mercaptopyridine-1-oxide sodium salt

zinc(II) chloride

zinc(II) sulfate monohydrate

zinc(II) nitrate

Refernces

• 1、 Higes-Rolando, F. J.,Perez-Florindo, A.,Valenzuela-Calahorro, C.. "". . p. 43 - 52. Retrieved 1991.
• 2、 King, Ryan C.,Nilewar, Shrikant,Sterenberg, Brian T.. "Phosphorus-carbon bond forming reactions of iron tetracarbonyl-coordinated phosphenium ions". . p. 68 - 74. Retrieved 2018/11/21.
• 3、 Pandey, Swechchha,Raj, K. Vipin,Shinde, Dinesh R.,Vanka, Kumar,Kashyap, Varchaswal,Kurungot, Sreekumar,Vinod,Chikkali, Samir H.. "Iron Catalyzed Hydroformylation of Alkenes under Mild Conditions: Evidence of an Fe(II) Catalyzed Process". supporting information. p. 4430 - 4439. Retrieved 2018/04/05.