nitrene chloride

Base Information

• Chemical Name: nitrene chloride
• CAS No.: 12190-75-9
• Molecular Formula: ClN
• Molecular Weight: 51.4756
• Mol file: 12190-75-9.mol

Synonyms:nitrene chloride

Chemical Property of nitrene chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of nitrene chloride

There total 88 articles about nitrene chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chlorine azide → nitrene chloride (12190-75-9,10599-90-3) + clorine (14700-96-0,14835-24-6,15723-23-6,16547-50-5,16885-04-4,16887-00-6,16904-11-3,16904-12-4,16999-02-3,20337-89-7,20499-73-4,22537-15-1,22537-27-5,22541-73-7,22541-74-8,24203-47-2,33944-49-9,34937-26-3,37352-90-2)

Guidance literature:

In neat (no solvent); byproducts: N3, N2; Irradiation (UV/VIS); dominate products by 248-nm photolysis: Cl+N3, also observed NCl+N2; monitored by TOF MS;

DOI:10.1016/j.cplett.2004.04.113

Reference yield: 94.0%

ammonia (7664-41-7) + chlorine (7782-50-5) → chloroamine (12190-75-9,10599-90-3) + nitrogen (7727-37-9) + ammonium chloride

Guidance literature:

In neat (no solvent); NH3:Cl2 = 39; at ambient temp.;;

DOI:10.1021/ja01644a010

Reference yield: 10.0%

sodium hypochlorite (7681-52-9) + ammonia (7664-41-7) → chloroamine (12190-75-9,10599-90-3) + sodium hydroxide (1310-73-2)

Guidance literature:

In water; very dild. soln. of NH2Cl is obtained;; distn. in vac. at 40°C;;

upstream raw materials:

ammonium sulfate

sodium hypochlorite

ammonia

ammonium chloride

Downstream raw materials:

1-(dichloromethyl)-4-methylbenzene

carbon dioxide

nitrogen

{(C₆H₅)3SbCl}2NH

Refernces

• 1、 Khoshniazi, Hamideh,Eshghi, Hossein,Tayarani-Najjaran, Mona,Tayarani-Najaran, Zahra,Saadat, Kayvan,Shiri, Ali. "Synthesis and antiproliferative assessments of new derivatives of isothiazolo[3,4-d]pyrimidine". . p. 193 - 201. Retrieved 2020/11/12.
• 2、 Spergel, Steven H.,Mertzman, Michael E.,Kempson, James,Guo, Junqing,Stachura, Sylwia,Haque, Lauren,Lippy, Jonathan S.,Zhang, Rosemary F.,Galella, Michael,Pitt, Sidney,Shen, Guoxiang,Fura, Aberra,Gillooly, Kathleen,McIntyre, Kim W.,Tang, Vicky,Tokarski, John,Sack, John S.,Khan, Javed,Carter, Percy H.,Barrish, Joel C.,Nadler, Steven G.,Salter-Cid, Luisa M.,Schieven, Gary L.,Wrobleski, Stephen T.,Pitts, William J.. "Discovery of a JAK1/3 Inhibitor and Use of a Prodrug to Demonstrate Efficacy in a Model of Rheumatoid Arthritis". supporting information. p. 306 - 311. Retrieved 2019/03/19.