7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1h-1,4-benzodiazepine-2-methanamine

Base Information Edit

Chemical Name:7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1h-1,4-benzodiazepine-2-methanamine
CAS No.:59467-64-0
Molecular Formula:C16H15ClFN3
Molecular Weight:303.767
Hs Code.:
UNII:S9JC45ZV43
DSSTox Substance ID:DTXSID50974868
Nikkaji Number:J2.153.048D
Mol file:59467-64-0.mol

Synonyms:59467-64-0;7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1h-1,4-benzodiazepine-2-methanamine;1216629-00-3;Midazolam amino compound;[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methanamine;S9JC45ZV43;Midazolam impurity E [EP];UNII-S9JC45ZV43;4-Amino-3-methylbutyric Acid Heminaphthalene-1,5-disulfonate;1H-1,4-Benzodiazepine-2-methanamine, 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-;2-aminomethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine;((2RS)-7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl)methanamine;[(2RS)-7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methanamine;LSQOUBKWMBDIPL-UHFFFAOYSA-N;SCHEMBL3053148;DTXSID50974868;AKOS015889491;MIDAZOLAM IMPURITY E [EP IMPURITY];NS00117948;1-[7-CHLORO-5-(2-FLUOROPHENYL)-2,3-DIHYDRO-1H-1,4-BENZODIAZEPIN-2-YL]METHANAMINE;2-aminomethyl-7 -chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine;2-aminomethyl-7-chloro-2,3-dihydro- 5-(2-fluorophenyl)-1H-1,4-benzodiazepine;2-aminomethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-bezodiazepine;Midazolam Imp. E (EP);Midazolam Impurity E

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Chemical Property of 7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1h-1,4-benzodiazepine-2-methanamine Edit

Chemical Property:

Vapor Pressure:5.21E-10mmHg at 25°C
Refractive Index:1.67
Boiling Point:443.9 °C at 760 mmHg
PKA:9.51±0.29(Predicted)
Flash Point:222.3 °C
PSA：30.18000
Density:1.362 g/cm³
LogP:3.75980
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:303.0938533
Heavy Atom Count:21
Complexity:390

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CN
Uses An Intermediate for the synthesis of Midazolam

Technology Process of 7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1h-1,4-benzodiazepine-2-methanamine

There total 5 articles about 7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1h-1,4-benzodiazepine-2-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: