trans-4-Methylcyclohexyl amine

Base Information

• Chemical Name: trans-4-Methylcyclohexyl amine
• CAS No.: 2523-55-9
• Molecular Formula: C7H15N
• Molecular Weight: 113.203
• Hs Code.: 2921300090
• Mol file: 2523-55-9.mol

Synonyms:Cyclohexylamine,4-methyl-, trans- (8CI);4-trans-Methylcyclohexylamine;trans-1-Amino-4-methylcyclohexane;trans-4-Methyl-1-cyclohexanamine;

Chemical Property of trans-4-Methylcyclohexyl amine

Chemical Property:

• Vapor Pressure: 4.049mmHg at 25°C
• Melting Point: -8.5°C (estimate)
• Refractive Index: 1.449
• Boiling Point: 149.324 °C at 760 mmHg
• PKA: 10.58±0.70(Predicted)
• Flash Point: 26.667 °C
• PSA: 26.02000
• Density: 0.845 g/cm³
• LogP: 2.22410
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

trans-4-Methylcyclohexylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 10-35-52-36-22
• Safety Statements: 16-28-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-4-Methylcyclohexyl amine

There total 16 articles about trans-4-Methylcyclohexyl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.6%

p-toluidine (106-49-0,12221-03-3) → trans-4-methylcyclohexanamine (2523-55-9) + cis-4-methylcyclohexanamine (2523-56-0) + 4,4'-dimethyldicyclohexylamine (84518-71-8,109667-09-6)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 110 ℃; for 3h; under 75007.5 Torr; Reagent/catalyst; Temperature; Kinetics; Autoclave;

DOI:10.1002/cctc.201701613

Reference yield:

p-toluidine (106-49-0,12221-03-3) → trans-4-methylcyclohexanamine (2523-55-9) + cis-4-methylcyclohexanamine (2523-56-0)

Guidance literature:

With hydrogenchloride; hydrogen; acetic acid; platinum; at 25 ℃; under 2280 Torr;

Reference yield:

p-cresol (106-44-5) → trans-4-methylcyclohexanamine (2523-55-9) + cis-4-methylcyclohexanamine (2523-56-0)

Guidance literature:

With methanol; 5% Rh/C; ammonia; hydrogen; isopropyl alcohol; In Hexadecane; at 140 ℃; for 16h; under 12001.2 Torr; Autoclave;

DOI:10.1002/cctc.201800486

upstream raw materials:

p-methylcyclohexanol

4-methylcyclohexanone oxime

p-toluidine

formamide

Downstream raw materials:

trans-4-benzamino-1-methyl-cyclohexane

dimethyl-(trans-4-methyl-cyclohexyl)-amine

N-(4-methyl-cyclohexyl)-N'-phenyl-urea

1-(2-chloroethyl)-3-(4-methylcyclohexyl)urea

Refernces

• 1、 Freidlin et al.. "". . . Retrieved 1973.
• 2、 Berglund, Per,Fiorati, Andrea,Humble, Maria S.,Tessaro, Davide. "Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates". supporting information. . Retrieved 2020/02/04.
• 3、 Tomkins, Patrick,Müller, Thomas E.. "Enhanced Selectivity in the Hydrogenation of Anilines to Cyclo-aliphatic Primary Amines over Lithium-Modified Ru/CNT Catalysts". . p. 1438 - 1445. Retrieved 2018/03/30.