Naloxone hydrochloride dihydrate

Base Information

• Chemical Name: Naloxone hydrochloride dihydrate
• CAS No.: 51481-60-8
• Molecular Formula: C19H21NO4^.HCl^.2(H2O)
• Molecular Weight: 399.87
• European Community (EC) Number: 610-669-6
• UNII: 5Q187997EE
• ChEMBL ID: CHEMBL5315056
• DSSTox Substance ID: DTXSID90199452
• RXCUI: 1010598
• Wikidata: Q27262715
• Mol file: 51481-60-8.mol

Synonyms:Naloxone hydrochloride dihydrate;51481-60-8;Naloxone chlorhydrate;Naloxone HCl Dihydrate;5Q187997EE;Naloxone.HCl.dihydrate;(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;dihydrate;hydrochloride;UNII-5Q187997EE;Naloxone Hydrochloride Dihydrate;Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, dihydrate, (5alpha)-;CHEMBL5315056;Naloxoni hydrochloridum dihydrate;DTXSID90199452;4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride dihydrate;TXMZWEASFRBVKY-IOQDSZRYSA-N;EX-A3584;MFCD00150901;s4501;AKOS030488390;NALOXONE DIHYDRATE HYDROCHLORIDE;PD040585;Naloxone.HCl.dihydrate, 1mg/ml in Methanol;4683H;NALOXONE HYDROCHLORIDE DIHYDRATE [MI];D11620;NALOXONE HYDROCHLORIDE DIHYDRATE [WHO-IP];Q-201445;NALOXONE HYDROCHLORIDE DIHYDRATE [EP MONOGRAPH];Q27262715;CASSIPA COMPONENT NALOXONE HYDROCHLORIDE DIHYDRATE;NALOXONI HYDROCHLORIDUM DIHYDRATE [WHO-IP LATIN];BUNAVAIL COMPONENT NALOXONE HYDROCHLORIDE DIHYDRATE;NALOXONE HYDROCHLORIDE DIHYDRATE COMPONENT OF CASSIPA;NALOXONE HYDROCHLORIDE DIHYDRATE COMPONENT OF BUNAVAIL;(-)-N-ALLYL-14-HYDROXYNORDIHYDROMORPHINONE HYDROCHLORIDE DIHYDRATE;Naloxone hydrochloride dihydrate, >=98% (TLC and titration), powder;Naloxone, Pharmaceutical Secondary Standard;Certified Reference Material;17-ALLYL-4,5.ALPHA.-EPOXY-3,14-DIHYDROXYMORPHINAN-6-ONE HYDROCHLORIDE DIHYDRATE;Naloxone for peak identification, European Pharmacopoeia (EP) Reference Standard;Naloxone Hydrochloride Dihydrate 1.0 mg/ml in Methanol (as anhydrous free base);Naloxone hydrochloride dihydrate, European Pharmacopoeia (EP) Reference Standard;(4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one hydrochloride dihydrate

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Chemical Property of Naloxone hydrochloride dihydrate

Chemical Property:

• Appearance/Colour: white to off-white powder
• Melting Point: 182 °C (dec.)(lit.)
• Flash Point: 288.4oC
• PSA: 88.46000
• LogP: 1.91270
• Storage Temp.: 2-8°C
• Solubility.: ethanol: 3.3 mg/mL stable for several months refrigerated i
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 399.1448652
• Heavy Atom Count: 27
• Complexity: 594

Purity/Quality:

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-26-36/37/39-36

MSDS Files:

Useful:

• Canonical SMILES: C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.O.O.Cl
• Isomeric SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.O.O.Cl
• Recent EU Clinical Trials: Double-blind, placebo-controlled randomised study on the efficacy of naloxone nasal spray for the treatment of gambling disorder
• Uses: Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.