(S)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: (S)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
• CAS No.: 67877-95-6
• Molecular Formula: C₁₀H₁₂N₂O₄*ClH
• Molecular Weight: 260.677
• Hs Code.: 2922499990
• Mol file: 67877-95-6.mol

Synonyms:D-Phenylalanine,4-nitro-, methyl ester, monohydrochloride (9CI); p-Nitro-D-phenylalaninemethyl ester hydrochloride

Chemical Property of (S)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Melting Point: 210-214oC
• PSA: 98.14000
• LogP: 2.66310
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Nitro-D-phenylalanineMethylEsterHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE

There total 12 articles about (S)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5) → (+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride (17193-40-7,67877-95-6,105359-55-5,108450-75-5)

Guidance literature:

With dmap; thionyl chloride; In methanol; di-isopropyl ether;

Reference yield: 92.0%

methanol (67-56-1) + 4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5) → (+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride (17193-40-7,67877-95-6,105359-55-5,108450-75-5)

Guidance literature:

With hydrogenchloride; at 10 ℃;

DOI:10.1002/chem.200204612

Reference yield:

Boc-Phe(p-NO2)-OH (33305-77-0) → (+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride (17193-40-7,67877-95-6,105359-55-5,108450-75-5)

Guidance literature:

With thionyl chloride; In methanol;

upstream raw materials:

hydrogenchloride

4-nitrophenylalanine

methanol

Boc-Phe(p-NO₂)-OH

Downstream raw materials:

4-Amino-N-carbobenzoxy-phenylalaninmethylester

4-Bromacetyl-amino-N-carbobenzoxy-phenylalaninmethylester

C₁₃H₁₂N₂O₅

Refernces

• 1、 Da Silva, Marcos Reinaldo,De Mattos, Marcos Carlos,De Oliveira, Maria Da Concei??o Ferreira,De Lemos, Telma Leda Gomes,Ricardo, Nágila Maria Pontes Silva,De Gonzalo, Gonzalo,Lavandera, Iván,Gotor-Fernández, Vicente,Gotor, Vicente. "Asymmetric chemoenzymatic synthesis of N-acetyl-α-amino esters based on lipase-catalyzed kinetic resolutions through interesterification reactions". . p. 2264 - 2271. Retrieved 2014/03/21.
• 2、 Chong, Hyun-Soon,Ma, Xiang,Le, Thien,Kwamena, Baidoo,Milenic, Diane E.,Brady, Erik D.,Song, Hyun A.,Brechbiel, Martin W.. "Rational design and generation of a bimodal bifunctional ligand for antibody-targeted radiation cancer therapy". . p. 118 - 125. Retrieved 2008/09/18.