H-PRA-OME HCL

Base Information

• Chemical Name: H-PRA-OME HCL
• CAS No.: 166271-28-9
• Molecular Formula: C₆H₉NO₂*ClH
• Molecular Weight: 163.604
• Mol file: 166271-28-9.mol

Synonyms:4-Pentynoicacid, 2-amino-, methyl ester, hydrochloride, (S)-

Chemical Property of H-PRA-OME HCL

Chemical Property:

• PSA: 52.32000
• LogP: 1.01230
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

L-Propargylglycine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PRA-OME HCL

There total 1 articles about H-PRA-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (R)-2-aminopent-4-ynoic acid (23235-01-0,23235-03-2,50428-03-0,64165-64-6) → methyl (R)-2-aminopent-4-ynoate hydrochloride (885105-50-0,166271-28-9)

Guidance literature:

methanol; (R)-2-aminopent-4-ynoic acid; With thionyl chloride; Inert atmosphere;

With hydrogenchloride; In water;

Reference yield:

methyl (R)-2-aminopent-4-ynoate hydrochloride (885105-50-0,166271-28-9) + 4-methoxy-phenyl-sulphonyl chloride (98-68-0) → methyl (R)-2-((4-methoxyphenyl)sulfonamido)pent-4-ynoate

Guidance literature:

With pyridine; dmap; at 0 - 20 ℃; for 24h; Inert atmosphere;

Reference yield:

(S)-1-methoxy-1-oxopent-4-yn-2-aminium chloride (166271-28-9) → C29H31N9O8

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: dichloromethane

3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 °C

3.2: 6 h / 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

methanol

(R)-2-aminopent-4-ynoic acid

Downstream raw materials:

methyl (2S)-2-(tert-butoxycarbonylamino)pent-4-ynoate

C₃₀H₃₃N₉O₈

(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

Refernces