N-Methyl-L-serine

Base Information

• Chemical Name: N-Methyl-L-serine
• CAS No.: 2480-26-4
• Molecular Formula: C4H9NO3
• Molecular Weight: 119.11900
• Hs Code.: 2922500090
• UNII: B6423FC3I2
• DSSTox Substance ID: DTXSID10179498
• Nikkaji Number: J101.067K
• Wikidata: Q27274419
• Mol file: 2480-26-4.mol

Synonyms:N-Methyl-L-serine;2480-26-4;H-N-Me-Ser-OH;methylserine;N-Methylserine;Aquaserine;(S)-3-Hydroxy-2-(methylamino)propanoic acid;Serine, N-methyl-, L-;H-Meser-OH;L-Serine, N-methyl;N-Me-Ser-OH;N-Methyl-(S)-serine;(2S)-3-Hydroxy-2-(methylamino)propanoic acid;L-Serine, N-methyl-;UNII-B6423FC3I2;(S)-3-Hydroxy-2-methylaminopropionic acid;(2S)-3-hydroxy-2-(methylazaniumyl)propanoate;B6423FC3I2;methyl-l-serine;L-Serine,N-methyl-;METHYLSERINE [INCI];SCHEMBL163350;DTXSID10179498;CHEBI:172327;MFCD00037756;AKOS006275623;CS-W013588;HY-W012872;N-Methyl-L-serine, >=98% (TLC);MS-22753;F10793;Q27274419

Chemical Property of N-Methyl-L-serine

Chemical Property:

• Vapor Pressure: 1.68E-05mmHg at 25°C
• Melting Point: 190℃ (dec.)
• Refractive Index: 1.479
• Boiling Point: 326.2 °C at 760 mmHg
• PKA: 2.17±0.10(Predicted)
• Flash Point: 151.1 °C
• Density: 1.242 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -2.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 119.058243149
• Heavy Atom Count: 8
• Complexity: 83.4

Purity/Quality:

98% ^*data from raw suppliers

N-Methyl-L-serine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(CO)C(=O)O
• Isomeric SMILES: CN[C@@H](CO)C(=O)O
• Uses: N-methyl-L-serine are used as topical compounds in anti-aging agents, cosmetic peptides, and skin-conditioning agents.

Technology Process of N-Methyl-L-serine

There total 6 articles about N-Methyl-L-serine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-2-(Benzhydryl-methyl-amino)-3-hydroxy-propionic acid benzhydryl ester → N-methyl-DL-serine (2480-26-4,915405-01-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4039(97)01132-5

Reference yield: 64.0%

N-benzyloxycarbonyl-N-methyl-L-serine (173947-21-2) → N-methyl-DL-serine (2480-26-4,915405-01-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;

DOI:10.1071/CH99082

Reference yield:

C15H27NO3 → N-methyl-D-serine (915405-01-5) + N-methyl-DL-serine (2480-26-4,915405-01-5)

Guidance literature:

C₁₅H₂₇NO₃; With hydrogenchloride; In ethanol; at 78 ℃; for 24h;

With methyloxirane; In ethanol; at 78 ℃; for 0.5h;

DOI:10.1055/s-0033-1340816

upstream raw materials:

formaldehyd

(S)-2-(benzylamino)-3-hydroxypropanoic acid

N-benzyloxycarbonyl-N-methyl-L-serine

L-serin

Downstream raw materials:

Fmoc-N-methyl-L-serine

Refernces

• 1、 Lim, David,Wen, Xiaojin,Seebeck, Florian P.. "Selenoimidazolium Salts as Supramolecular Reagents for Protein Alkylation". . p. 3515 - 3520. Retrieved 2020/09/21.
• 2、 Aurelio, Luigi,Brownlee, Robert T. C.,Hughes, Andrew B.,Sleebs, Brad E.. "The facile production of N-methyl amino acids via oxazolidinones". . p. 425 - 433. Retrieved 2007/10/03.